8-OHdG Elisa high sensitive
MOG-100P 100 µg of IgG
Produced in Japan.
Suitable for immunohistocheistry and ELISA. For research use only.
(Y.Hattori, et.al.: J Invest Dermatol 107, p733-737, 1996)
[ Immunohistochemistry of ferric nitrotriacetate-treated mouse kidney. ]
T. Ichiseki, A. Kaneuji, S. Katsuda1, Y. Ueda,T. Sugimori and T. Matsumoto: DNA Compounds harm in bone early after steroid administration is included in the pathogenesis of both steroid-induced osteonecrosis. Rheumatology 44,p456-460(2005)
Around 8-hydroxy-2′-deoxyguanosine (8-OHdG):
Japan Institute for the Control of Aging (JaICA), Nikken SEIL Co., Ltd.. Haruoka 710-1, Fukuroi, Shizuoka, Japan that is 437-0122
[ Application to person cultured cells.]
Y.Ihara, S.Toyokuni, K.Uchida, H.Odaka, T.Tanaka, H.Ikeda, H.Hiai, Y.Seino, and Y.Yamada: Hyperglycemia causes oxidative stress in pancreatic -cells of GK rats, a model of type 2 diabetes.
Anti 8-OHdG monoclonal antibody MOG-020P 20 µg of all IgG
T.Tanaka, Y.Nishiyama, K.Okada, K.Hirota, M.Matsui, J.Yodoi, H.Hiai, and S.Toyokuni: Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab. Invest.
Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of therapy stained with N45.1.
Anti-8-OHdG/ 8-oxo-dG/ / 8-hydroxy-2′-deoxyguanosine monoclonal antibody (N45.1).
Specifity of this antibody clone N45.1.
Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or alternative use.
[ Immunohistochemistry of UV-B irradiated mouse skin.]
S.Toyokuni, T.Tanaka, Y.Hattori, Y,Nishiyama, A.Yoshida, K.Uchida, H.Hiai, H.Ochi, and T.Osawa: Quantitative immunohistochemical determination of 8-hydroxy-2’deoxyguanosine with a monoclonal antibody N45.1: Its use to ferric nitrilotriacetate-induced renal carcinogenesis version. Lab. Invest. 76(3), p365-374 (1997)
Subclass: Mouse IgG1(kappa)
Home > Products > Antibodies > Anti 8-OHdG antibody [ Print page ] Rev.081027
Y.Hattori, C.Nishigori, T.Tanaka, K.Uchida, O.Nikaido, T.Osawa, H.Hiai, S.Imamura, and S.Toyokuni: 8-Hydroxy-2’deoxyguanosine is raised in epidermal cells of hairless mice after chronic ultraviolet B exposure. J. Invest. Dermatol.
Lee YA, Cho EJ, Yokozawa T: Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2 -induced cellular senescence. Biol Pharm Bull 31(6)p1265-1269(2008)
Records / MSDS
Associated products: New 8-OHdG Assess ELISA Highly sensitive 8-OHdG Check ELISA
[ Immunohistochemistry of pancreatic islets from GK rat, a diabetes model. ]
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Storage: Less than -20°C for 5 years
Reactive oxygen species (ROS) and oxidative stress may be critical for development of different diseases such as diabetes, cancer, and might play a significant role in the aging process. 8-hydroxy-2′-deoxyguanosine (8-OHdG) is a product of damaged DNA formed photodynamic action and by hydroxy radical, singlet oxygen. 8-OHdG can be detected in tissue, serum, urine and other biomaterials. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for DNA damage, not cross react with RNA oxidation items like 8-hydroxy-guanine and 8-hydroxy-guanosine. Suitable for immunohistochemistry and ELISA.
Education manual Immunohistochemical process Technical Information
Ready as ascite, and ammnonium sulphate purified.
Utilization: Immunohistochemistry and ELISA
Package: 20 or 100 µg of IgG / vial (MOG-020P and MOG-100P respectively).
Specificity: 19 analogues of 8-OHdG guanosine (G), 7-methyl-G, 6-SH-G, 8-bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine (Gua), O6-methyl-Gua, 8-OHGua, uric acid, Urea, creatine, creatinine demonstrate no cross-reactivity. Just 8-sulfhydryl-G and 8-OHG demonstrate minimal cross-reactivity (significantly less than 1%).
[ Immunohistochemistry of rabbit tissue. ]
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