Sirtuins in mammals: insights into their bioalogical function.

Sirtuins are a conserved household of proteins discovered in all domains of life. The first identified sirtuin, Sir2 (silent data regulator 2) of Saccharomyces cerevisiae, from which the household derives its title, regulates ribosomal DNA recombination, gene silencing, DNA restore, chromosomal stability and longevity. Sir2 homologues additionally modulate lifespan in worms and flies, and should underlie the useful results of caloric restriction, the one routine that slows growing older and extends lifespan of most lessons of organism, together with mammals.
Sirtuins have gained appreciable consideration for their influence on mammalian physiology, since they could present novel targets for treating illnesses related to growing older and maybe lengthen human lifespan. In this assessment we describe our present understanding of the biological operate of the seven mammalian sirtuins, SIRT1-7, and we will even focus on their potential as mediators of caloric restriction and as pharmacological targets to delay and deal with human age-related illnesses.
The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors in addition to to Caenorhabditis elegans daf-2, a sign transducer regulating worm dauer formation and grownup longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with as much as an 85% extension of grownup longevity and dwarf males with decreased late age-specific mortality.
Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy towards that of wild-type controls. We conclude that juvenile hormone deficiency, which ends up from InR sign pathway mutation, is ample to increase life-span, and that in flies, insulin-like ligands nonautonomously mediate growing older by retardation of progress or activation of particular endocrine tissue.
FOXO transcription components on the interface between longevity and tumor suppression.
A variety of human illnesses, together with most cancers, has a hanging age-dependent onset. However, the molecular mechanisms that join growing older and most cancers are simply starting to be unraveled. FOXO transcription components are promising candidates to function molecular hyperlinks between longevity and tumor suppression. These components are main substrates of the protein kinase Akt.
In the presence of insulin and progress components, FOXO proteins are relocalized from the nucleus to the cytoplasm and degraded through the ubiquitin-proteasome pathway. In the absence of progress components, FOXO proteins translocate to the nucleus and upregulate a sequence of goal genes, thereby selling cell cycle arrest, stress resistance, or apoptosis.
Stress stimuli additionally set off the relocalization of FOXO components into the nucleus, thus permitting an adaptive response to emphasize stimuli. Consistent with the notion that stress resistance is very coupled with lifespan extension, activation of FOXO transcription components in worms and flies will increase longevity. Emerging proof additionally means that FOXO components play a tumor suppressor position in a wide range of cancers. Thus, FOXO proteins translate environmental stimuli into modifications in gene expression applications which will coordinate organismal longevity and tumor suppression.
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all enhance the life spans of mannequin organisms. These mutations have revealed evolutionarily conserved pathways for growing older, a few of which seem to increase life span in response to sensory cues, caloric restriction, or stress. Many mutations affecting longevity pathways delay age-related illness, and the molecular evaluation of those pathways is resulting in a mechanistic understanding of how these two processes–growing older and illness susceptibility–are linked.
Inflammgrowing older and anti-inflammgrowing older: a systemic perspective on growing older and longevity emerged from research in people.
A big a part of the growing older phenotype, together with immunosenescence, is defined by an imbalance between inflammatory and anti-inflammatory networks, which ends up in the low grade persistent pro-inflammatory standing we proposed to name inflammgrowing older. Within this angle, wholesome growing older and longevity are possible the outcome not solely of a decrease propensity to mount inflammatory responses but additionally of environment friendly anti-inflammatory networks, which in regular growing older fail to completely neutralize the inflammatory processes consequent to the lifelong antigenic burden and publicity to damgrowing older brokers.
Such a world imbalance could be a main driving pressure for frailty and widespread age-related pathologies, and needs to be addressed and studied inside an evolutionary-based programs biology perspective. Evidence in favor of this conceptualization largely derives from research in people. We thus suggest that inflammgrowing older could be flanked by anti-inflammgrowing older as main determinants not solely of immunosenescence however ultimately of world growing older and longevity.
The FoxO household of Forkhead transcription components performs an vital position in longevity and tumor suppression by upregulating goal genes concerned in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription components translate a wide range of environmental stimuli, together with insulin, progress components, vitamins and oxidative stress, into particular gene-expression applications.
These environmental stimuli management FoxO exercise primarily by regulating their subcellular localization, but additionally by affecting their protein ranges, DNA-binding properties and transcriptional exercise. The exact regulation of FoxO transcription components is enacted by an intricate mixture of post-translational modifications (PTMs), together with phosphorylation, acetylation and ubiquitination, and binding protein companions.
![]() Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E01A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
|||
20-abx008040 | Abbexa |
|
|
|
![]() LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
|||
20-abx013801 | Abbexa |
|
|
|
![]() LAG1 Longevity Assurance Homolog 2 (LASS2) Antibody |
|||
abx019124-100ug | Abbexa | 100 ug | EUR 342 |
|
![]() LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody |
|||
abx430427-200ul | Abbexa | 200 ul | EUR 384 |
|
![]() Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E04A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E04A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E04A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E06A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E06A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E06A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E02A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E02A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E02A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E03A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E03A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E03A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E08A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E08A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E08A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E09A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E09A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E09A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E07A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E07A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E07A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
|||
KTE61853-48T | Abbkine | 48T | EUR 332 |
|
|||
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
![]() ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
|||
KTE61853-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2115 |
|
|||
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
![]() ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
|||
KTE61853-96T | Abbkine | 96T | EUR 539 |
|
|||
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
![]() Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E05A0057-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E05A0057-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
|||
E05A0057-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
20-abx258682 | Abbexa |
|
|
|
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
SER156Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5189.65 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
SER156Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 515.03 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
SER156Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 692.9 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
SER156Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2818.05 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
|||
4-SER156Hu | Cloud-Clone |
|
|
|
|||
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() Longevity Assurance Homolog 6 (LASS6) Antibody |
|||
abx029719-400ul | Abbexa | 400 ul | EUR 523 |
|
![]() Longevity Assurance Homolog 6 (LASS6) Antibody |
|||
abx029719-80l | Abbexa | 80 µl | EUR 286 |
|
![]() Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit |
|||
20-abx496220 | Abbexa |
|
|
|
![]() ELISA kit for Human LASS6 (Longevity Assurance Homolog 6) |
|||
ELK7613 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
|||
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
20-abx152171 | Abbexa |
|
|
|
![]() Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit |
|||
abx388232-96tests | Abbexa | 96 tests | EUR 911 |
|
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
DLR-LASS2-Hu-48T | DL Develop | 48T | EUR 554 |
|
|||
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
DLR-LASS2-Hu-96T | DL Develop | 96T | EUR 725 |
|
|||
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
RD-LASS2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 563 |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
RD-LASS2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 783 |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
RDR-LASS2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 589 |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
RDR-LASS2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 820 |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
SEP312Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5189.65 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
SEP312Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 515.03 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
SEP312Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 692.9 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
SEP312Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2818.05 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
|||
4-SEP312Hu | Cloud-Clone |
|
|
|
|||
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() Longevity Assurance Homolog 2 (LASS2) Antibody |
|||
20-abx173382 | Abbexa |
|
|
|
![]() Longevity Assurance Homolog 2 (LASS2) Antibody |
|||
20-abx177383 | Abbexa |
|
|
|
![]() Longevity Assurance Homolog 2 (LASS2) Antibody |
|||
abx234705-100ug | Abbexa | 100 ug | EUR 551 |
|
![]() Human Longevity Assurance Homolog 2 (LASS2) Protein |
|||
20-abx654210 | Abbexa |
|
|
|
![]() ELISA kit for Human LASS2 (Longevity Assurance Homolog 2) |
|||
ELK7214 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
|||
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit |
|||
20-abx496121 | Abbexa |
|
|
|
![]() Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody |
|||
abx432242-200ul | Abbexa | 200 ul | EUR 384 |
|
![]() Individual Reaction Mix 6 |
|||
G065-6 | ABM | 200 reactions | EUR 167 |
![]() Human B7H6/ B7 homolog 6 ELISA Kit |
|||
E2885Hu | Sunlong | 1 Kit | EUR 605 |
![]() Human B7H6(B7 homolog 6) ELISA Kit |
|||
EH2307 | FN Test | 96T | EUR 567.6 |
|
|||
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml |
![]() Human B7 homolog 6, B7H6 ELISA KIT |
|||
ELI-07534h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
20-abx151587 | Abbexa |
|
|
|
![]() Human Chromobox Homolog 6 (CBX6) ELISA Kit |
|||
20-abx386319 | Abbexa |
|
|
|
![]() Human Frizzled Homolog 6 (FZD6)ELISA Kit |
|||
201-12-2368 | SunredBio | 96 tests | EUR 440 |
|
|||
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
DLR-FZD6-Hu-48T | DL Develop | 48T | EUR 517 |
|
|||
Description: A sandwich quantitative ELISA assay kit for detection of Human Frizzled Homolog 6 (FZD6) in samples from tissue homogenates or other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
DLR-FZD6-Hu-96T | DL Develop | 96T | EUR 673 |
|
|||
Description: A sandwich quantitative ELISA assay kit for detection of Human Frizzled Homolog 6 (FZD6) in samples from tissue homogenates or other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
RD-FZD6-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 521 |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
RD-FZD6-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 723 |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
RDR-FZD6-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 544 |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
RDR-FZD6-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 756 |
![]() Human Frizzled Homolog 6(FZD6)ELISA Kit |
|||
QY-E02701 | Qayee Biotechnology | 96T | EUR 394 |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
SEE576Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4731.5 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Frizzled Homolog 6 (FZD6) in Tissue homogenates and other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
SEE576Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 477.3 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Frizzled Homolog 6 (FZD6) in Tissue homogenates and other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
SEE576Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 639 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Frizzled Homolog 6 (FZD6) in Tissue homogenates and other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
SEE576Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2575.5 |
|
|||
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Frizzled Homolog 6 (FZD6) in Tissue homogenates and other biological fluids. |
![]() Human Frizzled Homolog 6 (FZD6) ELISA Kit |
|||
4-SEE576Hu | Cloud-Clone |
|
|
|
|||
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Frizzled Homolog 6 (FZD6) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
![]() Random Nanofibers 6 Well Plate |
|||
3D00006-6 | Neuromics | 700 nm-PCLs | EUR 93 |
![]() Aligned Nanofibers 6 Well Plate |
|||
3D00012-6 | Neuromics | 700 nm-PCLs | EUR 97 |
![]() pLenti-CLDN1 shRNA-6 Plasmid |
|||
PVTBAV04867-6 | Lifescience Market | 2 ug | EUR 356 |
![]() Mouse IL-6 Recombinant Protein |
|||
R00102-6 | BosterBio | 5ug/vial | EUR 259 |
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Mouse IL-6 Recombinant Protein is purified interleukin-6 produced in yeast. |
![]() Tissue Culture Plate, 6 Well |
|||
TCP20-6 | Bio Basic | 1 UNIT | EUR 53.48 |
|
![]() ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 6 vials) |
|||
M1040-6 | Biovision | EUR 1300 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 6 vials) |
|||
M1041-6 | Biovision | EUR 1572 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 6 vials) |
|||
M1042-6 | Biovision | EUR 1300 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 6 vials) |
|||
M1043-6 | Biovision | EUR 1572 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials) |
|||
M1044-6 | Biovision | EUR 1289 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 6 vials) |
|||
M1045-6 | Biovision | EUR 1572 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 6 vials) |
|||
M1046-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 6 vials) |
|||
M1047-6 | Biovision | EUR 1621 |
![]() Aligned Nanofibers 6 Well Plate Inserts |
|||
3D00016-6 | Neuromics | 700 nm-PCLs | EUR 98 |
![]() Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed |
|||
ELISA-1 | Alpha Diagnostics | 1 | EUR 202 |
![]() Human Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E01C1423-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Human Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Human Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E01C1423-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Human Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Human Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E01C1423-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Human Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Human Chromobox protein homolog 6, CBX6 ELISA KIT |
|||
ELI-10763h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Seizure protein 6 homolog, SEZ6 ELISA KIT |
|||
ELI-13559h | Lifescience Market | 96 Tests | EUR 824 |
![]() ELISA kit for Human FZD6 (Frizzled Homolog 6) |
|||
ELK3914 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
|||
Description: A sandwich ELISA kit for detection of Frizzled Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Human Protein shisa- 6 homolog, SHISA6 ELISA KIT |
|||
ELI-39355h | Lifescience Market | 96 Tests | EUR 824 |
![]() AFP (Alpha fetoprotein) ELISA test |
|||
6 | Biobase | 96T/Box | Ask for price |
|
|||
Description: ELISA based test for quantitative detection of AFP (Alpha fetoprotein) |
![]() Mouse Mothers against decapentaplegic homolog 6,Smad 6 ELISA Kit |
|||
ELA-E2187m | Lifescience Market | 96 Tests | EUR 865 |
![]() Human Mothers against decapentaplegic homolog 6,Smad6 ELISA Kit |
|||
ELA-E2187h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Partitioning defective 6 homolog alpha, PARD6A ELISA KIT |
|||
ELI-14712h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Partitioning defective 6 homolog gamma, PARD6G ELISA KIT |
|||
ELI-21527h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Mothers against decapentaplegic homolog 6, SMAD6 ELISA KIT |
|||
ELI-07012h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Partitioning defective 6 homolog beta, PARD6B ELISA KIT |
|||
ELI-44903h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human THO complex subunit 6 homolog, THOC6 ELISA KIT |
|||
ELI-28883h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human WAS protein family homolog 6, WASH6P ELISA KIT |
|||
ELI-51493h | Lifescience Market | 96 Tests | EUR 824 |
![]() Human Partitioning Defective 6 Homolog Beta (PARD6B) ELISA Kit |
|||
abx382054-96tests | Abbexa | 96 tests | EUR 911 |
|
![]() Human Cell Division Cycle 6 Homolog (CDC6) ELISA Kit |
|||
abx386425-96tests | Abbexa | 96 tests | EUR 911 |
|
![]() Human Minichromosome Maintenance Deficient 6 Homolog (MCM6) ELISA Kit |
|||
abx257272-96tests | Abbexa | 96 tests | EUR 637 |
|
![]() Human Frizzled Homolog 6 (FZD6) CLIA Kit |
|||
20-abx494654 | Abbexa |
|
|
|
![]() ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 6 vials) |
|||
M1054-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 6 vials) |
|||
M1055-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 6 vials) |
|||
M1048-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 6 vials) |
|||
M1049-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 6 vials) |
|||
M1050-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 6 vials) |
|||
M1051-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 6 vials) |
|||
M1052-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 6 vials) |
|||
M1053-6 | Biovision | EUR 1572 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 6 vials) |
|||
M1058-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 6 vials) |
|||
M1059-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 6 vials) |
|||
M1060-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 6 vials) |
|||
M1061-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 6 vials) |
|||
M1064-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 6 vials) |
|||
M1065-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 6 vials) |
|||
M1066-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 6 vials) |
|||
M1067-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 6 vials) |
|||
M1070-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (1090 µg, B16F10 cell line, 6 vials) |
|||
M1071-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 6 vials) |
|||
M1062-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 6 vials) |
|||
M1063-6 | Biovision | EUR 1616 |
![]() ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 6 vials) |
|||
M1068-6 | Biovision | EUR 1306 |
![]() ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 6 vials) |
|||
M1069-6 | Biovision | EUR 1616 |
![]() Goat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E06C1423-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Goat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E06C1423-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Goat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E06C1423-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Goat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E02C1423-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E02C1423-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E02C1423-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
|||
Description: A competitive ELISA for quantitative measurement of Rat Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Mouse Chromobox protein homolog 6(CBX6) ELISA kit |
|||
E03C1423-192T | B-Gene | 192 tests | EUR 1270 |
|
|||
Description: A competitive ELISA for quantitative measurement of Mouse Chromobox protein homolog 6(CBX6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
An intriguing chance is that FoxO PTMs could act as a ‘molecular FoxO code’ learn by selective protein companions to quickly regulate gene-expression applications. The efficient management of FoxO exercise in response to environmental stimuli is prone to be important to stop growing older and age-dependent illnesses, together with most cancers, neurodegenerative illnesses and diabetes.