National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. – The Scientific Publications about Aging and Longevity

Medicinal Use of Testosterone and Related Steroids Revisited

May 23, 2021 Anthony Berry

Testosterone derivatives and associated compounds (comparable to anabolic-androgenic steroids-AAS) are often misused by athletes (each skilled and newbie) wishing to advertise muscle improvement and energy or to cowl AAS misuse. Even although these brokers are vastly thought to be abusive materials, they’ve vital pharmacological actions that can not be simply changed by different medicine and have therapeutic potential in a variety of circumstances (e.g., losing syndromes, extreme burns, muscle and bone accidents, anemia, hereditary angioedema).

Testosterone and associated steroids have been in some international locations handled as managed substances, which can have an effect on the provision of these brokers for sufferers who want them for therapeutic causes in a given nation. Although these brokers are at present thought to be reasonably older technology medicine and their use could result in critical side-effects, they nonetheless have medicinal worth as androgenic, anabolic, and even anti-androgenic brokers.

This evaluate summarizes and revisits the medicinal use of compounds based mostly on the construction and organic exercise of testosterone, with examples of particular compounds. Additionally, some of the newer androgenic-anabolic compounds are mentioned comparable to selective androgen receptor modulators, the efficacy/adverse-effect profiles of which haven’t been sufficiently established and which can pose a larger threat than typical androgenic-anabolic brokers.

Ten completely different Saccharomyces cerevisiae strains fermented semi-synthetic musts containing a Polyphenolic and Aroma Precursor Fraction (PAF) extracted from Tempranillo grapes. Aroma compounds have been studied by Gas Chromatography (GC), GC-Olfactometry and GC-Mass Spectrometry (MS), throughout fermentation by trapping volatilized aroma, instantly after fermentation and after accelerated getting old. Volatiles misplaced by evaporation throughout fermentation are largely fermentative compounds and not grape-related odorants.

Isobutanal and some esters are largely misplaced throughout fermentation. In many instances the impression of yeast pressure is obvious solely after getting old. Strains may very well be categorised into three main clusters with marked variations in fermentative and varietal profiles. Linalool and geraniol have been discovered to have fermentative origin. S. cerevisiae yeast strains can successfully modulate varietal aroma, probably via particular enzymatic actions appearing on grape phenolic acids and norisoprenoid aroma precursors and could also be particularly used to mitigate some getting old-related off odours, comparable to massoia lactone, guaiacol or TDN.

Growth Hormone and Aging: New Findings

Complex relationships between progress hormone (GH) signaling and mammalian getting old proceed to draw consideration of many investigators. Recent outcomes embody proof that the impression of GH on genome upkeep (DNA harm and restore) is drastically completely different in regular as in comparison with most cancers cells, in line with GH selling getting old and most cancers development. Impact of GH on DNA methylation was studied as a potential mechanism linking actions of GH throughout youth to the trajectory of getting old.

Animals with lowered or enhanced GH signaling and novel animals with adipocyte-specific deletion of GH receptors have been used to elucidate the consequences of GH on white and brown adipose tissue, together with the impression of this hormone on lipolysis, fibrosis, and thermogenesis. Effects of GH on adipose tissue associated to lipid and power metabolism emerge as mechanistic hyperlinks between GH, healthspan, and lifespan.

Treatment of wholesome males with a mixture of GH, dehydroepiandrosterone, and metformin was reported to revive thymus operate and scale back epigenetic age. Studies of human topics with deficiency of GH or GH receptors and research of mice with the identical endocrine syndromes recognized a number of phenotypic modifications associated (positively or negatively) to the beforehand reported predisposition to wholesome getting old.

Results of these and different latest research advance current understanding of the mechanisms by which GH influences getting old and longevity and of the trade-offs concerned. Periodic fasting (PF) is an more and more common method that assists within the administration of metabolic and inflammatory illnesses in addition to in stopping mechanisms concerned in getting old.

However, little is understood concerning the results of fasting on intestine microbiota and its impression on the epigenetic regulation of metabolically related enzymes, particularly sirtuins (SIRTs). We analyzed the impact of periodic fasting on the human intestine microbiota, SIRTs expression, and mitochondrial content material in 51 males and females. The members fasted beneath supervision for 5 consecutive days following the Buchinger fasting pointers.

Medicinal Use of Testosterone and Related Steroids Revisited

BiT age: A transcriptome-based getting old clock close to the theoretical restrict of accuracy

Aging clocks dissociate organic from chronological age. The estimation of organic age is vital for figuring out gerontogenes and assessing environmental, dietary, or therapeutic impacts on the getting old course of. Recently, methylation markers have been proven to permit estimation of organic age based mostly on age-dependent somatic epigenetic alterations. However, DNA methylation is absent in some species comparable to Caenorhabditis elegans and it stays unclear whether or not and how the epigenetic clocks have an effect on gene expression.

Aging clocks based mostly on transcriptomes have suffered from appreciable variation within the information and comparatively low accuracy. Here, we devised an method that makes use of temporal scaling and binarization of C. elegans transcriptomes to outline a gene set that predicts organic age with an accuracy that’s near the theoretical restrict. Our mannequin precisely predicts the longevity results of various strains, therapies, and circumstances.

The concerned genes help a task of particular transcription components in addition to innate immunity and neuronal signaling within the regulation of the getting old course of. We present that this binarized transcriptomic getting old (BiT age) clock can be utilized to human age prediction with excessive accuracy. The BiT age clock might due to this fact discover extensive software in genetic, dietary, environmental, and therapeutic interventions within the getting old course of.

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting

May 9, 2021 Anthony Berry

The growth of interventions aimed toward bettering healthspan is among the precedence duties for the educational and public well being authorities. It can be the principle goal of a novel department in biogerontological analysis, geroscience. According to the geroscience idea, targeting aging is an efficient solution to fight age-related problems. Since aging is an exceptionally advanced course of, system-oriented built-in approaches appear most acceptable for such an interventional technique.

Given the excessive plasticity and adaptability of the epigenome, epigenome-targeted interventions seem extremely promising in geroscience analysis. Pharmaceuticals focused at mechanisms concerned in epigenetic management of gene exercise are actively developed and applied to stop and deal with varied aging-related circumstances resembling cardiometabolic, neurodegenerative, inflammatory problems, and most cancers.

In this overview, we describe the roles of epigenetic mechanisms in aging; characterize enzymes contributing to the regulation of epigenetic processes; significantly concentrate on epigenetic medication, resembling inhibitors of DNA methyltransferases and histone deacetylases which will doubtlessly have an effect on aging-associated illnesses and longevity; and focus on potential caveats related to the usage of epigenetic medication.

Four waves of knowledge from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) have been collected and included 2440 Chinese aged people. The cognitive perform of aged people was measured utilizing the Mini Mental State Examination (MMSE). A nonnormal Growth Mixture mannequin (GMM) with 5 time-invariant covariates was used to determine the totally different trajectories of cognitive decline in aged people.

TA-65 doesn’t enhance telomere size throughout post-natal growth in home sparrow chicks (Passer domesticus)

Telomeres, protecting caps on the finish of chromosomes, are sometimes positively associated to lifespan and are regarded as an necessary mechanism of organismal aging. To higher perceive the informal relationships between telomere size and longevity, it’s important to have the ability to experimentally manipulate telomere dynamics (size and loss price).

Previous research recommend that publicity to TA-65, an extract from the Chinese root Astragalus membranaceus, prompts telomerase, lengthens telomeres, will increase the expansion of keratin-based buildings, and boosts the immune system in adults. However, telomere loss is anticipated to be biggest throughout adolescence however whether or not TA-65 has related results throughout this life stage is at the moment unknown.

Here, we experimentally uncovered free-living home sparrow (Passer domesticus) chicks to TA-65 throughout post-natal growth and examined the results on telomere size and loss, progress of keratin-based buildings, and a measure of mobile immunity. Contrary to expectation, the expansion of keratin-based buildings was decreased in TA-65 chicks and in the second yr of the examine, chicks uncovered to TA-65 skilled extra telomere loss than controls.

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

Aging is the best danger issue for a mess of illnesses together with heart problems, neurodegeneration and most cancers. Despite many years of analysis devoted to understanding aging, the mechanisms underlying the aging course of stay incompletely understood. The widely-accepted free radical idea of aging (FRTA) proposes that the buildup of oxidative injury attributable to reactive oxygen species (ROS) is among the major causes of aging.

To outline the connection between ROS and aging, there have been two major approaches: comparative research that measure outcomes associated to ROS throughout species with totally different lifespans, and experimental research that modulate ROS ranges inside a single species utilizing both a genetic or pharmacologic strategy. Comparative research have proven that ranges of ROS and oxidative injury are inversely correlated with lifespan. While these research in basic help the FRTA, any such experiment can solely exhibit correlation, not causation.

Experimental research involving the manipulation of ROS ranges in mannequin organisms have typically proven that interventions that enhance ROS are inclined to lower lifespan, whereas interventions that lower ROS have a tendency to extend lifespan. However, there are additionally a number of examples in which the other is noticed: rising ROS ranges outcomes in prolonged longevity, and lowering ROS ranges outcomes in shortened lifespan. While these research contradict the predictions of the FRTA, these experiments have been carried out in a really restricted variety of species, all of which have a comparatively quick lifespan.

Overall, the info recommend that the connection between ROS and lifespan is advanced, and that ROS can have each useful or detrimental results on longevity relying on the species and circumstances. Accordingly, the connection between ROS and aging is tough to generalize throughout the tree of life. Vitamin D deficiency is frequent amongst older adults, however its affiliation with bodily perform just isn’t totally understood. The purpose of this examine was to analyze the associations between serum 25-hydroxyvitamin D and incapacity in actions of day by day dwelling (ADL), mobility, and goal bodily functioning amongst Chinese older adults.

AAV-3 Helper Free Packaging System
VPK-403	Cell Biolabs	1 kit	EUR 972
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Packaging System
VPK-404	Cell Biolabs	1 kit	EUR 972
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Packaging System
VPK-406	Cell Biolabs	1 kit	EUR 972
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Packaging System
VPK-400-DJ-8	Cell Biolabs	1 kit	EUR 972
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Expression System
VPK-410-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Promoterless Expression System
VPK-411-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ Helper Free Expression System
VPK-410-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Expression System
VPK-410-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Expression System
VPK-410-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Expression System
VPK-410-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Expression System
VPK-410-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Expression System
VPK-410-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Expression System
VPK-410-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ Helper Free Promoterless Expression System
VPK-411-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Promoterless Expression System
VPK-411-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Promoterless Expression System
VPK-411-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Promoterless Expression System
VPK-411-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Promoterless Expression System
VPK-411-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Promoterless Expression System
VPK-411-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Promoterless Expression System
VPK-411-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ Helper Free Bicistronic Expression System (Puro)
VPK-415-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Bicistronic Expression System (Puro)
VPK-415-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ Helper Free Bicistronic Expression System (Neo)
VPK-416-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Bicistronic Expression System (Neo)
VPK-416-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ Helper Free Bicistronic Expression System (Hygro)
VPK-417-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Bicistronic Expression System (Hygro)
VPK-417-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ Helper Free Bicistronic Expression System (GFP)
VPK-418-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Bicistronic Expression System (GFP)
VPK-418-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

AAV-1 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-5 Helper Free Expression System
VPK-430-SER5	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Bicistronic Expression System (Puro)
VPK-415-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Neo)
VPK-416-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Hygro)
VPK-417-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (GFP)
VPK-418-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

scAAV-DJ Helper Free Expression System
VPK-430-DJ	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

scAAV-1 Helper Free Expression System
VPK-430-SER1	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-2 Helper Free Expression System
VPK-430-SER2	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-3 Helper Free Expression System
VPK-430-SER3	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-4 Helper Free Expression System
VPK-430-SER4	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-6 Helper Free Expression System
VPK-430-SER6	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-DJ/8 Helper Free Expression System
VPK-430-DJ-8	Cell Biolabs	1 kit	EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

ViraSafe Lentiviral Packaging System, Ecotropic
VPK-205	Cell Biolabs	1 kit	EUR 891
Description: Our ViraSafe Lentiviral Packaging Systems contain three packaging plasmids for co-transfection with your own third generation lentiviral expression construct. If you need an expression vector as well as the packaging plasmids, consider our ViraSafe Lentiviral Expression Complete Systems. Our Ecotropic Packaging System assembles lentiviruses with an ecotropic envelope protein which will readily infect only mouse and rat cells via receptor-mediated binding, providing an additional level of safety. However, ecotropic viruses are not as stable upon freezing and will not survive ultracentrifugation procedure

ViraSafe Lentiviral Packaging System, Pantropic
VPK-206	Cell Biolabs	1 kit	EUR 891
Description: Our ViraSafe Lentiviral Packaging Systems contain three packaging plasmids for co-transfection with your own third generation lentiviral expression construct. If you need an expression vector as well as the packaging plasmids, consider our ViraSafe Lentiviral Expression Complete Systems. The Pantropic Packaging System assembles VSVG-pseudotyped lentiviruses which can easily infect virtually any cells regardless of their species of origin.

ViraDuctin AAV Transduction Kit (10 Transductions)
AAV-200	Cell Biolabs	10 transductions	EUR 421
Description: The process by which adeno-associated virus (AAV) infects host cells includes viral binding and entry, intracellular trafficking, nuclear transport, and viral second strand DNA synthesis. The second strand DNA synthesis has been shown to be the rate limiting step, which leads to inefficient transduction by AAV vectors. ViraDuctin AAV Transduction Kit is a proprietary, multi-reagent formulation designed to increase the efficiency of transduction by AAV vectors. Reagent preparation takes only 10 minutes prior to host cell infection.

ViraDuctin AAV Transduction Kit (50 Transductions)
AAV-201	Cell Biolabs	50 transductions	EUR 972
Description: The process by which adeno-associated virus (AAV) infects host cells includes viral binding and entry, intracellular trafficking, nuclear transport, and viral second strand DNA synthesis. The second strand DNA synthesis has been shown to be the rate limiting step, which leads to inefficient transduction by AAV vectors. ViraDuctin AAV Transduction Kit is a proprietary, multi-reagent formulation designed to increase the efficiency of transduction by AAV vectors. Reagent preparation takes only 10 minutes prior to host cell infection.

Human Free PSA (f-PSA) ELISA Kit
PRB-5049-FREE-5	Cell Biolabs	5 x 96 assays	EUR 2283

Human Free PSA (f-PSA) ELISA Kit
PRB-5049-FREE	Cell Biolabs	96 assays	EUR 572

pPACKF1 FIV Lentivector Packaging Kit (50 reactions)
LV100A-5	SBI	50 transfections	EUR 2341

ViraBind AAV Purification Mega Kit
VPK-141-5	Cell Biolabs	10 preps	EUR 2312
Description: Purification of adeno-associated virus (AAV) using ultracentrifugation is tedious and time-consuming, and yields can be low. Our ViraBind AAV Purification Kits use a single-step proprietary purification matrix, followed by further purification and concentration with a centrifugal concentrator. The result is a higher viral yield with exceptional purity in a fraction of the time.

Lentivirus Packaging Kit
P904	101Bio	-	Ask for price

Retrovirus Packaging Kit
P905	101Bio	-	Ask for price

TRH, Free Acid
5-02022	CHI Scientific	4 x 5mg	Ask for price

TRH (free acid)
5-02023	CHI Scientific	4 x 5mg	Ask for price

Adrenorphin, Free Acid
5-00628	CHI Scientific	4 x 5mg	Ask for price

Adrenorphin, Free Acid
A1017-5	ApexBio	5 mg	EUR 102
Description: Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain(1).

A23187, free acid
B6646-5	ApexBio	5 mg	EUR 141
Description: A23187, free acid is a Ca2+ ionophore [1]. Ca2+ ionophore acts as a Ca2+ ionophore, allowing Ca2+ to cross cell membranes. A23187, free acid is a Ca2+ ionophore.

LY2835219 free base
A3575-5	ApexBio	5 mg	EUR 142
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

R406 (free base)
A5880-5	ApexBio	5 mg	EUR 166
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

Rucaparib (free base)
A8893-5	ApexBio	5 mg	EUR 137
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Ionomycin free acid
B6947-5	ApexBio	5 mg	EUR 254
Description: Ionomycin is a selective and potent calcium ionophore, which acts as a motile Ca2+ carrier.by direct stimulation of store-regulated cation entry across biological membranes, ionomycin can effectively enhance Ca2+ influx.

MCC950 (Free base)
B1031-5	Biovision		EUR 457

Apatinib (Free base)
B1613-5	Biovision		EUR 142

Carubicin (Free base)
B1853-5	Biovision		EUR 457

Anlotinib, free base
B2156-5	Biovision		EUR 185

FIPI (free base)
B2372-5	Biovision		EUR 196

Pemafibrate, Free Acid
B2670-5	Biovision	5mg	EUR 166

PLX5622 (free base)
B2965-5	Biovision	5 mg	EUR 227

THZ1 (Free base)
9664-5	Biovision		EUR 294

Ionomycin (free acid)
1565-5	Biovision		EUR 463

We used cross-sectional information of 2225 older adults (≥65 years) who participated in the 2011/2012 major survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Serum ranges of 25-hydroxyvitamin D have been measured by enzyme immunoassay. Outcomes included ADL incapacity, mobility incapacity, and incapacity in three goal bodily examinations (standing-up from a chair, picking-up a e-book from the ground, and turning-around 360°).

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis.

April 13, 2021 Anthony Berry

A progressive lack of neurons with age underlies quite a lot of debilitating neurological issues, together with Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), but few efficient therapies are at present accessible. The SIR2 gene promotes longevity in quite a lot of organisms and might underlie the well being advantages of caloric restriction, a weight-reduction plan that delays ageing and neurodegeneration in mammals. Here, we report {that a} human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in main neurons challenged with neurotoxic insults.

In cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, each promote neuronal survival. In the inducible p25 transgenic mouse, a mannequin of AD and tauopathies, resveratrol lowered neurodegeneration in the hippocampus, prevented studying impairment, and decreased the acetylation of the recognized SIRT1 substrates PGC-1alpha and p53. Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred vital safety against neurodegeneration. Thus, SIRT1 constitutes a singular molecular hyperlink between ageing and human neurodegenerative issues and supplies a promising avenue for therapeutic intervention.

Telomere upkeep is assumed to play a task in signaling mobile senescence; nevertheless, a hyperlink with organismal ageing processes has not been established. The telomerase null mouse supplies a possibility to grasp the consequences related to vital telomere shortening on the organismal degree. We studied quite a lot of physiological processes in an ageing cohort of mTR-/- mice. Loss of telomere perform didn’t elicit a full spectrum of classical pathophysiological signs of ageing.

However, age-dependent telomere shortening and accompanying genetic instability have been related to shortened life span in addition to a lowered capability to reply to stresses comparable to wound therapeutic and hematopoietic ablation. In addition, we discovered an elevated incidence of spontaneous malignancies. These findings show a vital function for telomere size in the general health, reserve, and properly being of the ageing organism.

Direct inhibition of the longevity-promoting issue SKN-1 by insulin-like signaling in C. elegans.

Insulin/IGF-1-like signaling (IIS) is central to progress and metabolism and has a conserved function in ageing. In C. elegans, reductions in IIS improve stress resistance and longevity, results that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription issue SKN-1 additionally defends against oxidative stress by mobilizing the conserved part 2 detoxing response. Here we present that IIS not solely opposes DAF-16 but additionally straight inhibits SKN-1 in parallel.

The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and lowered IIS results in constitutive SKN-1 nuclear accumulation in the gut and SKN-1 goal gene activation. SKN-1 contributes to the elevated stress tolerance and longevity ensuing from lowered IIS and delays ageing when expressed transgenically. Furthermore, SKN-1 that’s constitutively lively will increase life span independently of DAF-16. Our findings point out that the transcription community regulated by SKN-1 promotes longevity and is a crucial direct goal of IIS.

Aberrant protein aggregation is a typical characteristic of late-onset neurodegenerative ailments, together with Alzheimer’s disease, which is related to the misassembly of the Abeta(1-42) peptide. Aggregation-mediated Abeta(1-42) toxicity was lowered in Caenorhabditis elegans when ageing was slowed by decreased insulin/insulin progress factor-1-like signaling (IIS).

The downstream transcription elements, warmth shock issue 1, and DAF-16 regulate opposing disaggregation and aggregation actions to advertise mobile survival in response to constitutive poisonous protein aggregation. Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these outcomes counsel a mechanistic hyperlink between the ageing course of and aggregation-mediated proteotoxicity.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

SIRT6 hyperlinks histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Members of the sirtuin (SIRT) household of NAD-dependent deacetylases promote longevity in a number of organisms. Deficiency of mammalian SIRT6 results in shortened life span and an ageing-like phenotype in mice, however the underlying molecular mechanisms are unclear. Here we present that SIRT6 capabilities at chromatin to attenuate NF-kappaB signaling.

SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB goal gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these goal promoters is related to elevated RELA promoter occupancy and enhanced NF-kappaB-dependent modulation of gene expression, apoptosis, and mobile senescence.

Computational genomics analyses revealed elevated exercise of NF-kappaB-driven gene expression packages in a number of Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice. We suggest that SIRT6 attenuates NF-kappaB signaling through H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling might contribute to untimely and regular ageing.

The life span of C. elegans will be elevated through lowered perform of the mitochondria; nevertheless, the extent to which mitochondrial alteration in a single, distinct tissue might affect ageing in the entire organism stays unknown. We addressed this query by asking whether or not manipulations to ETC perform can modulate ageing in a cell-non-autonomous style.

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-80l	Abbexa	80 µl	EUR 286

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
20-abx152171	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit
20-abx496121	Abbexa	EUR 8569.00 EUR 4560.00 EUR 1052.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit
abx388232-96tests	Abbexa	96 tests	EUR 911

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-48T	DL Develop	48T	EUR 554

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-96T	DL Develop	96T	EUR 725

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 589

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 820

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 563

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 783

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
4-SEP312Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx013801	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx008040	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody
abx430427-200ul	Abbexa	200 ul	EUR 384

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)
ELK7214	ELK Biotech	1 plate of 96 wells	EUR 432

Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit
20-abx496220	Abbexa	EUR 8569.00 EUR 4560.00 EUR 1052.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
20-abx258682	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
4-SER156Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-48T	Abbkine	48T	EUR 332

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-96T	Abbkine	96T	EUR 539

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-200ul	Abbexa	200 ul	EUR 384

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)
ELK7613	ELK Biotech	1 plate of 96 wells	EUR 432

Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E01A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E01A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-48T	Abbkine	48T	EUR 332

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-96T	Abbkine	96T	EUR 539

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human MutY homolog Control/blocking peptide #2
MUTY12-P	Alpha Diagnostics	100 ug	EUR 164

Mouse Tubby/TUB homolog Control/blocking peptide # 2
TUBBY12-P	Alpha Diagnostics	100 ug	EUR 164

Mouse Mitochondrial carrier homolog 2 (Mtch2) Control/blocking peptide
AB-23027-P	Alpha Diagnostics	100ug	EUR 164

Prune Homolog 2 Peptide
46-888P	ProSci	0.1 mg	EUR 338
Description: PRUNE2 / BMCC1 Peptide

Ribosome Biogenesis Regulator Homolog (RRS1) Blocking Peptide
20-abx061186	Abbexa	EUR 286.00 EUR 425.00	1 mg 5 mg

Human Tub Homolog Control/blocking peptide # 3
TUBH31-P	Alpha Diagnostics	100 ug	EUR 164

Plakophilin 2 Blocking Peptide
20-abx061683	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg

EPHB1 / 2 Blocking Peptide
20-abx061724	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg

Neuropilin 2 Blocking Peptide
20-abx061738	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg

LATS1 / 2 Blocking Peptide
20-abx061790	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg

cGK 2 Blocking Peptide
20-abx061792	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg

LIMK1 / 2 Blocking Peptide
20-abx062150	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

ABL1 / 2 Blocking Peptide
20-abx062199	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Fibulin 2 Blocking Peptide
20-abx062609	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

GAD1 / 2 Blocking Peptide
20-abx062651	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Orosomucoid 2 Blocking Peptide
20-abx063036	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Profilin 2 Blocking Peptide
20-abx063073	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

cGK 2 Blocking Peptide
20-abx063137	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

ERK1 / 2 Blocking Peptide
20-abx063138	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

ERK1 / 2 Blocking Peptide
20-abx063139	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

ERK1 / 2 Blocking Peptide
20-abx063140	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Ataxin 2 Blocking Peptide
20-abx063240	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

SGK1 / 2 Blocking Peptide
20-abx063258	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Contactin 2 Blocking Peptide
20-abx063329	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Transglutaminase 2 Blocking Peptide
20-abx063353	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Cullin 2 Blocking Peptide
20-abx063472	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Urotensin 2 Blocking Peptide
20-abx063711	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Thioredoxin 2 Blocking Peptide
20-abx063792	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Cerebellin 2 Blocking Peptide
20-abx064069	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Angiopoietin 2 Blocking Peptide
20-abx064121	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Dectin 2 Blocking Peptide
20-abx161078	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Nidogen 2 Blocking Peptide
20-abx161180	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Relaxin 2 Blocking Peptide
20-abx161208	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

Aquaporin 2 Blocking Peptide
20-abx161278	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

We report that the alteration of mitochondrial perform in key tissues is crucial for establishing and sustaining a professionallongevity cue. We discover that regulators of mitochondrial stress responses are important and particular genetic necessities for the electron transport chain (ETC) longevity pathway. Strikingly, we discover that mitochondrial perturbation in one tissue is perceived and acted upon by the mitochondrial stress response pathway in a distal tissue.

FOXO3A genotype is strongly associated with human longevity.

April 9, 2021 Anthony Berry

Human longevity is a fancy phenotype with a major familial part, but little is recognized about its genetic antecedents. Increasing proof from animal fashions means that the insulin/IGF-1 signaling (IIS) pathway is an necessary, evolutionarily conserved organic pathway that influences growing old and longevity. However, so far human knowledge have been scarce. Studies have been hampered by small pattern sizes, lack of exact phenotyping, and inhabitants stratification, amongst different challenges.

Therefore, to extra exactly assess potential genetic contributions to human longevity from genes linked to IIS signaling, we selected a big, homogeneous, long-lived inhabitants of males well-characterized for growing old phenotypes, and we carried out a nested-case management research of 5 candidate longevity genes. Genetic variation inside the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous main alleles between the instances and controls was 2.75 (P = 0.00009; adjusted P = 0.00135).

Long-lived males additionally introduced a number of extra phenotypes linked to wholesome growing old, together with decrease prevalence of most cancers and heart problems, higher self-reported well being, and excessive bodily and cognitive perform, regardless of considerably older ages than controls. Several of those growing old phenotypes had been associated with FOXO3A genotype. Long-lived males additionally exhibited a number of organic markers indicative of larger insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and different growing old phenotypes is warranted in different populations.

Oxidative stress influences cell survival and homeostasis, however the mechanisms underlying the organic results of oxidative stress stay to be elucidated. Here, we reveal that the protein kinase MST1 mediates oxidative-stress-induced cell dying in main mammalian neurons by straight activating the FOXO transcription elements. MST1 phosphorylates FOXO proteins at a conserved website inside the forkhead area that disrupts their interplay with 14-3-Three proteins, promotes FOXO nuclear translocation, and thereby induces cell dying in neurons.

We additionally prolong the MST-FOXO signaling hyperlink to nematodes. Knockdown of the C. elegans MST1 ortholog CST-1 shortens life span and accelerates tissue growing old, whereas overexpression of cst-1 promotes life span and delays growing old. The cst-1-induced life-span extension happens in a daf-16-dependent method. The identification of the FOXO transcription elements as main and evolutionarily conserved targets of MST1 means that MST kinases play necessary roles in various organic processes together with mobile responses to oxidative stress and longevity.

Astrocytes as Perspective Targets of Exercise- and Caloric Restriction-Mimetics

Enhanced psychological and bodily exercise can have constructive results on the perform of growing old mind, each within the experimental animals and human sufferers, though mobile mechanisms underlying these results are presently unclear. There is a rising proof that pre-clinical stage of many neurodegenerative illnesses includes modifications in interactions between astrocytes and neurons. Conversely, astrocytes are strategically positioned to mediate the constructive affect of bodily exercise and food regimen on neuronal perform.

Thus, improvement of therapeutic brokers which might enhance the astroglia-neuron communications in ageing mind is of essential significance. Recent advances in research of mobile mechanisms of mind longevity counsel that astrocyte-neuron communications have a significant function within the useful results of caloric restriction, bodily train and their pharmacological mimetics on synaptic homeostasis and cognitive perform.

In explicit, our current knowledge point out that noradrenaline uptake inhibitor atomoxetine can improve astrocytic Ca²⁺-signaling and astroglia-driven modulation of synaptic plasticity. Similar results had been exhibited by caloric restriction-mimetics metformin and resveratrol. The emerged knowledge additionally counsel that astrocytes may very well be concerned within the modulatory motion of caloric restriction and its mimetics on neuronal autophagy. Still, the effectivity of astrocyte-targeting compounds in stopping age-related cognitive decline is but to be absolutely explored, specifically within the animal fashions of neurodegenerative illnesses and autophagy impairment.

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure

The World Health Organization estimates that solely roughly 25% of range in longevity is defined by genetic elements, whereas the opposite 75% is largely decided by interactions with the bodily and social environments. Indeed, growing old is a multifactorial course of that is influenced by a spread of environmental, sociodemographic, and biopsychosocial elements, all of which could act in live performance to find out the method of growing old.

The international common life expectancy elevated basically over the previous century, towards an growing old inhabitants, correlating with the event and onset of age-related illnesses, primarily from cardiovascular and neurological nature. Therefore, the identification of determinants of wholesome and unhealthy growing old is a significant aim to decrease the burden and socioeconomic prices of age-related illnesses.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx008040	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx013801	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

LAG1 Longevity Assurance Homolog 2 (LASS2) Antibody
abx019124-100ug	Abbexa	100 ug	EUR 342

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-48T	Abbkine	48T	EUR 332

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-96T	Abbkine	96T	EUR 539

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-48T	Abbkine	48T	EUR 332

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-96T	Abbkine	96T	EUR 539

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-400ul	Abbexa	400 ul	EUR 523

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-80l	Abbexa	80 µl	EUR 286

Longevity Assurance Homolog 2 (LASS2) Antibody
abx234705-100ug	Abbexa	100 ug	EUR 551

Longevity Assurance Homolog 2 (LASS2) Antibody
20-abx177383	Abbexa	EUR 1316.00 EUR 620.00	1 mg 200 ug

Longevity Assurance Homolog 2 (LASS2) Antibody
20-abx173382	Abbexa	EUR 926.00 EUR 467.00	1 mg 200 ug

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
4-SEP312Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
4-SER156Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 563

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 783

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-48T	DL Develop	48T	EUR 554

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-96T	DL Develop	96T	EUR 725

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
20-abx152171	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit
abx388232-96tests	Abbexa	96 tests	EUR 911

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
20-abx258682	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 589

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 820

Human Longevity Assurance Homolog 2 (LASS2) Protein
20-abx654210	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)
ELK7214	ELK Biotech	1 plate of 96 wells	EUR 432

Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)
ELK7613	ELK Biotech	1 plate of 96 wells	EUR 432

Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit
20-abx496121	Abbexa	EUR 8569.00 EUR 4560.00 EUR 1052.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit
20-abx496220	Abbexa	EUR 8569.00 EUR 4560.00 EUR 1052.00	10 × 96 tests 5 × 96 tests 96 tests

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-200ul	Abbexa	200 ul	EUR 384

Porcine Protein canopy homolog 3, CNPY3 ELISA KIT
ELI-10589p	Lifescience Market	96 Tests	EUR 928

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed
ELISA-1	Alpha Diagnostics	1	EUR 202

Porcine Slit2(Slit Homolog 2) ELISA Kit
EP0151	FN Test	96T	EUR 567.6

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 0.188 ng/ml

Porcine Protein maelstrom homolog, MAEL ELISA KIT
ELI-43029p	Lifescience Market	96 Tests	EUR 928

Porcine Protein Muted homolog, MUTED ELISA KIT
ELI-36857p	Lifescience Market	96 Tests	EUR 928

Porcine Teashirt homolog 2, TSHZ2 ELISA KIT
ELI-40365p	Lifescience Market	96 Tests	EUR 928

Porcine Lambda- crystallin homolog, CRYL1 ELISA KIT
ELI-10463p	Lifescience Market	96 Tests	EUR 928

Slit2 ELISA Kit\| Porcine Slit Homolog 2 ELISA Kit
EF016691	Lifescience Market	96 Tests	EUR 689

Porcine Mothors Against Decapentaplegic Homolog 1 ELISA Kit
EPS0012	Abclonal	96Tests	EUR 521

Porcine Protein slowmo homolog 2, SLMO2 ELISA KIT
ELI-41005p	Lifescience Market	96 Tests	EUR 928

Porcine Protein delta homolog 2, DLK2 ELISA KIT
ELI-47133p	Lifescience Market	96 Tests	EUR 928

Porcine Wilms tumor protein homolog, WT1 ELISA KIT
ELI-17852p	Lifescience Market	96 Tests	EUR 928

Porcine Enhancer of rudimentary homolog, ERH ELISA KIT
ELI-09715p	Lifescience Market	96 Tests	EUR 928

Porcine Mothers against decapentaplegic homolog 3, SMAD3 ELISA K
ELI-07004p	Lifescience Market	96 Tests	EUR 928

Porcine AQP-3 ELISA Kit
EPA0473	Abclonal	96Tests	EUR 521

Porcine 3-NT ELISA Kit
EPA0677	Abclonal	96Tests	EUR 521

Porcine Caspase-3 ELISA Kit
EPC0556	Abclonal	96Tests	EUR 521

Porcine CA15-3 ELISA Kit
EPC0677	Abclonal	96Tests	EUR 521

Porcine CCSA-3 ELISA Kit
EPC0717	Abclonal	96Tests	EUR 521

Porcine CED-3 ELISA Kit
EPC0735	Abclonal	96Tests	EUR 521

Porcine ENOS-3 ELISA Kit
EPE0165	Abclonal	96Tests	EUR 521

Porcine GSK-3 ELISA Kit
EPG0031	Abclonal	96Tests	EUR 521

Porcine ICAM-3 ELISA Kit
EPI0336	Abclonal	96Tests	EUR 521

Porcine IL-3 ELISA Kit
EPI0390	Abclonal	96Tests	EUR 521

Porcine LFA-3 ELISA Kit
EPL0233	Abclonal	96Tests	EUR 521

Porcine MMP-3 ELISA Kit
EPM0023	Abclonal	96Tests	EUR 521

Porcine MCP-3 ELISA Kit
EPM0257	Abclonal	96Tests	EUR 521

Porcine NT-3 ELISA Kit
EPN0025	Abclonal	96Tests	EUR 521

Porcine PI-3 ELISA Kit
EPP0751	Abclonal	96Tests	EUR 521

Porcine TIMP-3 ELISA Kit
EPT0525	Abclonal	96Tests	EUR 521

Porcine VEGFR 3 ELISA Kit
EPV0018	Abclonal	96Tests	EUR 521

Porcine Interleukin 3 ELISA Kit
ELA-E0076p	Lifescience Market	96 Tests	EUR 928

Porcine Complement 3 ELISA Kit
ELA-E0861p	Lifescience Market	96 Tests	EUR 928

Porcine Pachytene checkpoint protein 2 homolog, TRIP13 ELISA KIT
ELI-21517p	Lifescience Market	96 Tests	EUR 928

The function of environmental elements (comparable to air air pollution and noise publicity) as essential determinants of the growing old course of are being more and more acknowledged. Here, we critically assessment current findings in regards to the pathomechanisms underlying the growing old course of and their correlates in cardiovascular and neurological illness, centered on oxidative stress and irritation, in addition to the affect of outstanding environmental pollution, particularly air air pollution and visitors noise publicity.

Sirtuins in mammals: insights into their bioalogical function.

March 9, 2021 Anthony Berry

Sirtuins are a conserved household of proteins discovered in all domains of life. The first identified sirtuin, Sir2 (silent data regulator 2) of Saccharomyces cerevisiae, from which the household derives its title, regulates ribosomal DNA recombination, gene silencing, DNA restore, chromosomal stability and longevity. Sir2 homologues additionally modulate lifespan in worms and flies, and should underlie the useful results of caloric restriction, the one routine that slows growing older and extends lifespan of most lessons of organism, together with mammals.

Sirtuins have gained appreciable consideration for their influence on mammalian physiology, since they could present novel targets for treating illnesses related to growing older and maybe lengthen human lifespan. In this assessment we describe our present understanding of the biological operate of the seven mammalian sirtuins, SIRT1-7, and we will even focus on their potential as mediators of caloric restriction and as pharmacological targets to delay and deal with human age-related illnesses.

The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors in addition to to Caenorhabditis elegans daf-2, a sign transducer regulating worm dauer formation and grownup longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with as much as an 85% extension of grownup longevity and dwarf males with decreased late age-specific mortality.

Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy towards that of wild-type controls. We conclude that juvenile hormone deficiency, which ends up from InR sign pathway mutation, is ample to increase life-span, and that in flies, insulin-like ligands nonautonomously mediate growing older by retardation of progress or activation of particular endocrine tissue.

FOXO transcription components on the interface between longevity and tumor suppression.

A variety of human illnesses, together with most cancers, has a hanging age-dependent onset. However, the molecular mechanisms that join growing older and most cancers are simply starting to be unraveled. FOXO transcription components are promising candidates to function molecular hyperlinks between longevity and tumor suppression. These components are main substrates of the protein kinase Akt.

In the presence of insulin and progress components, FOXO proteins are relocalized from the nucleus to the cytoplasm and degraded through the ubiquitin-proteasome pathway. In the absence of progress components, FOXO proteins translocate to the nucleus and upregulate a sequence of goal genes, thereby selling cell cycle arrest, stress resistance, or apoptosis.

Stress stimuli additionally set off the relocalization of FOXO components into the nucleus, thus permitting an adaptive response to emphasize stimuli. Consistent with the notion that stress resistance is very coupled with lifespan extension, activation of FOXO transcription components in worms and flies will increase longevity. Emerging proof additionally means that FOXO components play a tumor suppressor position in a wide range of cancers. Thus, FOXO proteins translate environmental stimuli into modifications in gene expression applications which will coordinate organismal longevity and tumor suppression.

Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all enhance the life spans of mannequin organisms. These mutations have revealed evolutionarily conserved pathways for growing older, a few of which seem to increase life span in response to sensory cues, caloric restriction, or stress. Many mutations affecting longevity pathways delay age-related illness, and the molecular evaluation of those pathways is resulting in a mechanistic understanding of how these two processes–growing older and illness susceptibility–are linked.

Sirtuins in mammals: insights into their bioalogical function.

Inflammgrowing older and anti-inflammgrowing older: a systemic perspective on growing older and longevity emerged from research in people.

A big a part of the growing older phenotype, together with immunosenescence, is defined by an imbalance between inflammatory and anti-inflammatory networks, which ends up in the low grade persistent pro-inflammatory standing we proposed to name inflammgrowing older. Within this angle, wholesome growing older and longevity are possible the outcome not solely of a decrease propensity to mount inflammatory responses but additionally of environment friendly anti-inflammatory networks, which in regular growing older fail to completely neutralize the inflammatory processes consequent to the lifelong antigenic burden and publicity to damgrowing older brokers.

Such a world imbalance could be a main driving pressure for frailty and widespread age-related pathologies, and needs to be addressed and studied inside an evolutionary-based programs biology perspective. Evidence in favor of this conceptualization largely derives from research in people. We thus suggest that inflammgrowing older could be flanked by anti-inflammgrowing older as main determinants not solely of immunosenescence however ultimately of world growing older and longevity.

The FoxO household of Forkhead transcription components performs an vital position in longevity and tumor suppression by upregulating goal genes concerned in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription components translate a wide range of environmental stimuli, together with insulin, progress components, vitamins and oxidative stress, into particular gene-expression applications.

These environmental stimuli management FoxO exercise primarily by regulating their subcellular localization, but additionally by affecting their protein ranges, DNA-binding properties and transcriptional exercise. The exact regulation of FoxO transcription components is enacted by an intricate mixture of post-translational modifications (PTMs), together with phosphorylation, acetylation and ubiquitination, and binding protein companions.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E01A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-48T	Abbkine	48T	EUR 332

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-96T	Abbkine	96T	EUR 539

Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-192T	BlueGene	192 tests	EUR 1270

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-48	BlueGene	1 plate of 48 wells	EUR 520

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-96	BlueGene	1 plate of 96 wells	EUR 685

Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
4-SER156Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
20-abx258682	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-400ul	Abbexa	400 ul	EUR 523

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-80l	Abbexa	80 µl	EUR 286

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit
20-abx496220	Abbexa	EUR 8569.00 EUR 4560.00 EUR 1052.00	10 × 96 tests 5 × 96 tests 96 tests

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)
ELK7613	ELK Biotech	1 plate of 96 wells	EUR 432

Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
4-SEP312Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 563

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 783

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-48T	DL Develop	48T	EUR 554

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-96T	DL Develop	96T	EUR 725

Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
20-abx152171	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit
abx388232-96tests	Abbexa	96 tests	EUR 911

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48Tests	Reddot Biotech

Medicinal Use of Testosterone and Related Steroids Revisited

Growth Hormone and Aging: New Findings

BiT age: A transcriptome-based getting old clock close to the theoretical restrict of accuracy

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting

TA-65 doesn’t enhance telomere size throughout post-natal growth in home sparrow chicks (Passer domesticus)

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

AAV-3 Helper Free Packaging System

AAV-4 Helper Free Packaging System

AAV-6 Helper Free Packaging System

AAV-DJ/8 Helper Free Packaging System

AAV-5 Helper Free Expression System

AAV-5 Helper Free Promoterless Expression System

AAV-5 Helper Free Bicistronic Expression System (Puro)

AAV-5 Helper Free Bicistronic Expression System (Neo)

AAV-5 Helper Free Bicistronic Expression System (Hygro)

AAV-5 Helper Free Bicistronic Expression System (GFP)

AAV-5 Helper Free Bicistronic Expression System (Blasticidin)

AAV-DJ Helper Free Expression System

AAV-1 Helper Free Expression System

AAV-2 Helper Free Expression System

AAV-3 Helper Free Expression System

AAV-4 Helper Free Expression System

AAV-6 Helper Free Expression System

AAV-DJ/8 Helper Free Expression System

AAV-DJ Helper Free Promoterless Expression System

AAV-1 Helper Free Promoterless Expression System

AAV-2 Helper Free Promoterless Expression System

AAV-3 Helper Free Promoterless Expression System

AAV-4 Helper Free Promoterless Expression System

AAV-6 Helper Free Promoterless Expression System

AAV-DJ/8 Helper Free Promoterless Expression System

AAV-DJ Helper Free Bicistronic Expression System (Puro)

AAV-1 Helper Free Bicistronic Expression System (Puro)

AAV-2 Helper Free Bicistronic Expression System (Puro)

AAV-3 Helper Free Bicistronic Expression System (Puro)

AAV-4 Helper Free Bicistronic Expression System (Puro)

AAV-6 Helper Free Bicistronic Expression System (Puro)

AAV-DJ Helper Free Bicistronic Expression System (Neo)

AAV-1 Helper Free Bicistronic Expression System (Neo)

AAV-2 Helper Free Bicistronic Expression System (Neo)

AAV-3 Helper Free Bicistronic Expression System (Neo)

AAV-4 Helper Free Bicistronic Expression System (Neo)

AAV-6 Helper Free Bicistronic Expression System (Neo)

AAV-DJ Helper Free Bicistronic Expression System (Hygro)

AAV-1 Helper Free Bicistronic Expression System (Hygro)

AAV-2 Helper Free Bicistronic Expression System (Hygro)

AAV-3 Helper Free Bicistronic Expression System (Hygro)

AAV-4 Helper Free Bicistronic Expression System (Hygro)

AAV-6 Helper Free Bicistronic Expression System (Hygro)

AAV-DJ Helper Free Bicistronic Expression System (GFP)

AAV-1 Helper Free Bicistronic Expression System (GFP)

AAV-2 Helper Free Bicistronic Expression System (GFP)

AAV-3 Helper Free Bicistronic Expression System (GFP)

AAV-4 Helper Free Bicistronic Expression System (GFP)

AAV-6 Helper Free Bicistronic Expression System (GFP)

AAV-DJ Helper Free Bicistronic Expression System (Blasticidin)

AAV-1 Helper Free Bicistronic Expression System (Blasticidin)

AAV-2 Helper Free Bicistronic Expression System (Blasticidin)

AAV-3 Helper Free Bicistronic Expression System (Blasticidin)

AAV-4 Helper Free Bicistronic Expression System (Blasticidin)

AAV-6 Helper Free Bicistronic Expression System (Blasticidin)

scAAV-5 Helper Free Expression System

AAV-DJ/8 Helper Free Bicistronic Expression System (Puro)

AAV-DJ/8 Helper Free Bicistronic Expression System (Neo)

AAV-DJ/8 Helper Free Bicistronic Expression System (Hygro)

AAV-DJ/8 Helper Free Bicistronic Expression System (GFP)

AAV-DJ/8 Helper Free Bicistronic Expression System (Blasticidin)

scAAV-DJ Helper Free Expression System

scAAV-1 Helper Free Expression System

scAAV-2 Helper Free Expression System

scAAV-3 Helper Free Expression System

scAAV-4 Helper Free Expression System

scAAV-6 Helper Free Expression System

scAAV-DJ/8 Helper Free Expression System

ViraSafe Lentiviral Packaging System, Ecotropic

ViraSafe Lentiviral Packaging System, Pantropic

ViraDuctin AAV Transduction Kit (10 Transductions)

ViraDuctin AAV Transduction Kit (50 Transductions)

Human Free PSA (f-PSA) ELISA Kit

Human Free PSA (f-PSA) ELISA Kit