SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

A progressive lack of neurons with age underlies quite a lot of debilitating neurological issues, together with Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), but few efficient therapies are at present accessible. The SIR2 gene promotes longevity in quite a lot of organisms and might underlie the well being advantages of caloric restriction, a weight-reduction plan that delays ageing and neurodegeneration in mammals. Here, we report {that a} human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in main neurons challenged with neurotoxic insults.

In cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, each promote neuronal survival. In the inducible p25 transgenic mouse, a mannequin of AD and tauopathies, resveratrol lowered neurodegeneration in the hippocampus, prevented studying impairment, and decreased the acetylation of the recognized SIRT1 substrates PGC-1alpha and p53. Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred vital safety against neurodegeneration. Thus, SIRT1 constitutes a singular molecular hyperlink between ageing and human neurodegenerative issues and supplies a promising avenue for therapeutic intervention.

Telomere upkeep is assumed to play a task in signaling mobile senescence; nevertheless, a hyperlink with organismal ageing processes has not been established. The telomerase null mouse supplies a possibility to grasp the consequences related to vital telomere shortening on the organismal degree. We studied quite a lot of physiological processes in an ageing cohort of mTR-/- mice. Loss of telomere perform didn’t elicit a full spectrum of classical pathophysiological signs of ageing.

However, age-dependent telomere shortening and accompanying genetic instability have been related to shortened life span in addition to a lowered capability to reply to stresses comparable to wound therapeutic and hematopoietic ablation. In addition, we discovered an elevated incidence of spontaneous malignancies. These findings show a vital function for telomere size in the general health, reserve, and properly being of the ageing organism.

Direct inhibition of the longevity-promoting issue SKN-1 by insulin-like signaling in C. elegans.

 

Insulin/IGF-1-like signaling (IIS) is central to progress and metabolism and has a conserved function in ageing. In C. elegans, reductions in IIS improve stress resistance and longevity, results that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription issue SKN-1 additionally defends against oxidative stress by mobilizing the conserved part 2 detoxing response. Here we present that IIS not solely opposes DAF-16 but additionally straight inhibits SKN-1 in parallel.

The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and lowered IIS results in constitutive SKN-1 nuclear accumulation in the gut and SKN-1 goal gene activation. SKN-1 contributes to the elevated stress tolerance and longevity ensuing from lowered IIS and delays ageing when expressed transgenically. Furthermore, SKN-1 that’s constitutively lively will increase life span independently of DAF-16. Our findings point out that the transcription community regulated by SKN-1 promotes longevity and is a crucial direct goal of IIS.

Aberrant protein aggregation is a typical characteristic of late-onset neurodegenerative ailments, together with Alzheimer’s disease, which is related to the misassembly of the Abeta(1-42) peptide. Aggregation-mediated Abeta(1-42) toxicity was lowered in Caenorhabditis elegans when ageing was slowed by decreased insulin/insulin progress factor-1-like signaling (IIS).

The downstream transcription elements, warmth shock issue 1, and DAF-16 regulate opposing disaggregation and aggregation actions to advertise mobile survival in response to constitutive poisonous protein aggregation. Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these outcomes counsel a mechanistic hyperlink between the ageing course of and aggregation-mediated proteotoxicity.

 SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

SIRT6 hyperlinks histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Members of the sirtuin (SIRT) household of NAD-dependent deacetylases promote longevity in a number of organisms. Deficiency of mammalian SIRT6 results in shortened life span and an ageing-like phenotype in mice, however the underlying molecular mechanisms are unclear. Here we present that SIRT6 capabilities at chromatin to attenuate NF-kappaB signaling.

SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB goal gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these goal promoters is related to elevated RELA promoter occupancy and enhanced NF-kappaB-dependent modulation of gene expression, apoptosis, and mobile senescence.

Computational genomics analyses revealed elevated exercise of NF-kappaB-driven gene expression packages in a number of Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice. We suggest that SIRT6 attenuates NF-kappaB signaling through H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling might contribute to untimely and regular ageing.

The life span of C. elegans will be elevated through lowered perform of the mitochondria; nevertheless, the extent to which mitochondrial alteration in a single, distinct tissue might affect ageing in the entire organism stays unknown. We addressed this query by asking whether or not manipulations to ETC perform can modulate ageing in a cell-non-autonomous style.

Longevity Assurance Homolog 6 (LASS6) Antibody

abx029719-80l 80 µl
EUR 286

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

20-abx152171
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit

20-abx496121
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit

abx388232-96tests 96 tests
EUR 911

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

DLR-LASS2-Hu-48T 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

DLR-LASS2-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RDR-LASS2-Hu-48Tests 48 Tests
EUR 589

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RDR-LASS2-Hu-96Tests 96 Tests
EUR 820

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RD-LASS2-Hu-48Tests 48 Tests
EUR 563

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RD-LASS2-Hu-96Tests 96 Tests
EUR 783

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-10x96wellstestplate 10x96-wells test plate
EUR 5189.65
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-1x48wellstestplate 1x48-wells test plate
EUR 515.03
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-1x96wellstestplate 1x96-wells test plate
EUR 692.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-5x96wellstestplate 5x96-wells test plate
EUR 2818.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

4-SEP312Hu
  • EUR 5240.00
  • EUR 2769.00
  • EUR 693.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody

20-abx013801
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody

20-abx008040
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody

abx430427-200ul 200 ul
EUR 384

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)

ELK7214 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit

20-abx496220
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

20-abx258682
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-10x96wellstestplate 10x96-wells test plate
EUR 5189.65
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-1x48wellstestplate 1x48-wells test plate
EUR 515.03
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-1x96wellstestplate 1x96-wells test plate
EUR 692.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-5x96wellstestplate 5x96-wells test plate
EUR 2818.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

4-SER156Hu
  • EUR 5240.00
  • EUR 2769.00
  • EUR 693.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody

abx432242-200ul 200 ul
EUR 384

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)

ELK7613 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E01A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E01A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human MutY homolog Control/blocking peptide #2

MUTY12-P 100 ug
EUR 164

Mouse Tubby/TUB homolog Control/blocking peptide # 2

TUBBY12-P 100 ug
EUR 164

Mouse Mitochondrial carrier homolog 2 (Mtch2) Control/blocking peptide

AB-23027-P 100ug
EUR 164

Prune Homolog 2 Peptide

46-888P 0.1 mg
EUR 338
Description: PRUNE2 / BMCC1 Peptide

Ribosome Biogenesis Regulator Homolog (RRS1) Blocking Peptide

20-abx061186
  • EUR 286.00
  • EUR 425.00
  • 1 mg
  • 5 mg

Human Tub Homolog Control/blocking peptide # 3

TUBH31-P 100 ug
EUR 164

Plakophilin 2 Blocking Peptide

20-abx061683
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

EPHB1 / 2 Blocking Peptide

20-abx061724
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

Neuropilin 2 Blocking Peptide

20-abx061738
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

LATS1 / 2 Blocking Peptide

20-abx061790
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

cGK 2 Blocking Peptide

20-abx061792
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

LIMK1 / 2 Blocking Peptide

20-abx062150
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

ABL1 / 2 Blocking Peptide

20-abx062199
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Fibulin 2 Blocking Peptide

20-abx062609
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

GAD1 / 2 Blocking Peptide

20-abx062651
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Orosomucoid 2 Blocking Peptide

20-abx063036
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Profilin 2 Blocking Peptide

20-abx063073
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

cGK 2 Blocking Peptide

20-abx063137
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

ERK1 / 2 Blocking Peptide

20-abx063138
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

ERK1 / 2 Blocking Peptide

20-abx063139
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

ERK1 / 2 Blocking Peptide

20-abx063140
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Ataxin 2 Blocking Peptide

20-abx063240
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

SGK1 / 2 Blocking Peptide

20-abx063258
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Contactin 2 Blocking Peptide

20-abx063329
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Transglutaminase 2 Blocking Peptide

20-abx063353
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Cullin 2 Blocking Peptide

20-abx063472
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Urotensin 2 Blocking Peptide

20-abx063711
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Thioredoxin 2 Blocking Peptide

20-abx063792
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Cerebellin 2 Blocking Peptide

20-abx064069
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Angiopoietin 2 Blocking Peptide

20-abx064121
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Dectin 2 Blocking Peptide

20-abx161078
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Nidogen 2 Blocking Peptide

20-abx161180
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Relaxin 2 Blocking Peptide

20-abx161208
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Aquaporin 2 Blocking Peptide

20-abx161278
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

We report that the alteration of mitochondrial perform in key tissues is crucial for establishing and sustaining a professionallongevity cue. We discover that regulators of mitochondrial stress responses are important and particular genetic necessities for the electron transport chain (ETC) longevity pathway. Strikingly, we discover that mitochondrial perturbation in one tissue is perceived and acted upon by the mitochondrial stress response pathway in a distal tissue.