Direct inhibition of the longevity-promoting issue SKN-1 by insulin-like signaling in C. elegans.
Insulin/IGF-1-like signaling (IIS) is central to progress and metabolism and has a conserved function in ageing. In C. elegans, reductions in IIS improve stress resistance and longevity, results that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription issue SKN-1 additionally defends against oxidative stress by mobilizing the conserved part 2 detoxing response. Here we present that IIS not solely opposes DAF-16 but additionally straight inhibits SKN-1 in parallel.
The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and lowered IIS results in constitutive SKN-1 nuclear accumulation in the gut and SKN-1 goal gene activation. SKN-1 contributes to the elevated stress tolerance and longevity ensuing from lowered IIS and delays ageing when expressed transgenically. Furthermore, SKN-1 that’s constitutively lively will increase life span independently of DAF-16. Our findings point out that the transcription community regulated by SKN-1 promotes longevity and is a crucial direct goal of IIS.
Aberrant protein aggregation is a typical characteristic of late-onset neurodegenerative ailments, together with Alzheimer’s disease, which is related to the misassembly of the Abeta(1-42) peptide. Aggregation-mediated Abeta(1-42) toxicity was lowered in Caenorhabditis elegans when ageing was slowed by decreased insulin/insulin progress factor-1-like signaling (IIS).
The downstream transcription elements, warmth shock issue 1, and DAF-16 regulate opposing disaggregation and aggregation actions to advertise mobile survival in response to constitutive poisonous protein aggregation. Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these outcomes counsel a mechanistic hyperlink between the ageing course of and aggregation-mediated proteotoxicity.

SIRT6 hyperlinks histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Members of the sirtuin (SIRT) household of NAD-dependent deacetylases promote longevity in a number of organisms. Deficiency of mammalian SIRT6 results in shortened life span and an ageing-like phenotype in mice, however the underlying molecular mechanisms are unclear. Here we present that SIRT6 capabilities at chromatin to attenuate NF-kappaB signaling.
SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB goal gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these goal promoters is related to elevated RELA promoter occupancy and enhanced NF-kappaB-dependent modulation of gene expression, apoptosis, and mobile senescence.
Computational genomics analyses revealed elevated exercise of NF-kappaB-driven gene expression packages in a number of Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice. We suggest that SIRT6 attenuates NF-kappaB signaling through H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling might contribute to untimely and regular ageing.
The life span of C. elegans will be elevated through lowered perform of the mitochondria; nevertheless, the extent to which mitochondrial alteration in a single, distinct tissue might affect ageing in the entire organism stays unknown. We addressed this query by asking whether or not manipulations to ETC perform can modulate ageing in a cell-non-autonomous style.
Longevity Assurance Homolog 6 (LASS6) Antibody |
abx029719-80l |
Abbexa |
80 µl |
EUR 286 |
|
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5189.65 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 515.03 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 692.9 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2818.05 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
4-SEP312Hu |
Cloud-Clone |
-
EUR 5240.00
-
EUR 2769.00
-
EUR 693.00
|
-
10 plates of 96 wells
-
5 plates of 96 wells
-
1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
20-abx152171 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit |
20-abx496121 |
Abbexa |
-
EUR 8569.00
-
EUR 4560.00
-
EUR 1052.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit |
abx388232-96tests |
Abbexa |
96 tests |
EUR 911 |
|
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DLR-LASS2-Hu-48T |
DL Develop |
48T |
EUR 554 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DLR-LASS2-Hu-96T |
DL Develop |
96T |
EUR 725 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 589 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 820 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 563 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 783 |
LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
20-abx013801 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
-
100 ug
-
10 ug
-
200 ug
-
300 µg
|
|
LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
20-abx008040 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody |
abx430427-200ul |
Abbexa |
200 ul |
EUR 384 |
|
ELISA kit for Human LASS2 (Longevity Assurance Homolog 2) |
ELK7214 |
ELK Biotech |
1 plate of 96 wells |
EUR 432 |
|
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5189.65 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 515.03 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 692.9 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2818.05 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
4-SER156Hu |
Cloud-Clone |
-
EUR 5240.00
-
EUR 2769.00
-
EUR 693.00
|
-
10 plates of 96 wells
-
5 plates of 96 wells
-
1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit |
20-abx496220 |
Abbexa |
-
EUR 8569.00
-
EUR 4560.00
-
EUR 1052.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
20-abx258682 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E01A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E01A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E02A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E02A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E02A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody |
abx432242-200ul |
Abbexa |
200 ul |
EUR 384 |
|
ELISA kit for Human LASS6 (Longevity Assurance Homolog 6) |
ELK7613 |
ELK Biotech |
1 plate of 96 wells |
EUR 432 |
|
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Human MutY homolog Control/blocking peptide #2 |
MUTY12-P |
Alpha Diagnostics |
100 ug |
EUR 164 |
Mouse Tubby/TUB homolog Control/blocking peptide # 2 |
TUBBY12-P |
Alpha Diagnostics |
100 ug |
EUR 164 |
Mouse Mitochondrial carrier homolog 2 (Mtch2) Control/blocking peptide |
AB-23027-P |
Alpha Diagnostics |
100ug |
EUR 164 |
Claudin 2 Blocking Peptide |
AF0128-BP |
Affbiotech |
1mg |
EUR 195 |
Cullin 2 Blocking Peptide |
AF0141-BP |
Affbiotech |
1mg |
EUR 195 |
ERK1/2 Blocking Peptide |
AF0155-BP |
Affbiotech |
1mg |
EUR 195 |
TALL-2 Blocking Peptide |
AF0424-BP |
Affbiotech |
1mg |
EUR 195 |
AP-2 Blocking Peptide |
AF0535-BP |
Affbiotech |
1mg |
EUR 195 |
GAD1/2 Blocking Peptide |
AF0711-BP |
Affbiotech |
1mg |
EUR 195 |
BCL-2 Blocking Peptide |
AF0769-BP |
Affbiotech |
1mg |
EUR 195 |
PKM1/2 Blocking Peptide |
AF4031-BP |
Affbiotech |
1mg |
EUR 195 |
E2F-2 Blocking Peptide |
AF4100-BP |
Affbiotech |
1mg |
EUR 195 |
p56Dok-2 Blocking Peptide |
AF4683-BP |
Affbiotech |
1mg |
EUR 195 |
Bcl-2 Blocking Peptide |
AF4700-BP |
Affbiotech |
1mg |
EUR 195 |
Interleukin 2 Blocking Peptide |
AF5105-BP |
Affbiotech |
1mg |
EUR 195 |
ANG 2 Blocking Peptide |
AF5124-BP |
Affbiotech |
1mg |
EUR 195 |
HO 2 Blocking Peptide |
AF5143-BP |
Affbiotech |
1mg |
EUR 195 |
PAI 2 Blocking Peptide |
AF5174-BP |
Affbiotech |
1mg |
EUR 195 |
AP 2 Blocking Peptide |
AF5323-BP |
Affbiotech |
1mg |
EUR 195 |
MMP 2 Blocking Peptide |
AF5330-BP |
Affbiotech |
1mg |
EUR 195 |
Fra 2 Blocking Peptide |
AF5345-BP |
Affbiotech |
1mg |
EUR 195 |
TALL-2 Blocking Peptide |
AF5377-BP |
Affbiotech |
1mg |
EUR 195 |
Caveolin 2 Blocking Peptide |
AF5409-BP |
Affbiotech |
1mg |
EUR 195 |
BCL-2 Blocking Peptide |
AF6139-BP |
Affbiotech |
1mg |
EUR 195 |
ERK1/2 Blocking Peptide |
AF6240-BP |
Affbiotech |
1mg |
EUR 195 |
EFNB1/2 Blocking Peptide |
AF6343-BP |
Affbiotech |
1mg |
EUR 195 |
LIMK1/2 Blocking Peptide |
AF6344-BP |
Affbiotech |
1mg |
EUR 195 |
MEK1/2 Blocking Peptide |
AF6384-BP |
Affbiotech |
1mg |
EUR 195 |
MEK1/2 Blocking Peptide |
AF6385-BP |
Affbiotech |
1mg |
EUR 195 |
SHP-2 Blocking Peptide |
AF6412-BP |
Affbiotech |
1mg |
EUR 195 |
SHP-2 Blocking Peptide |
AF6413-BP |
Affbiotech |
1mg |
EUR 195 |
DRP-2 Blocking Peptide |
AF6459-BP |
Affbiotech |
1mg |
EUR 195 |
HER-2 Blocking Peptide |
BF0077-BP |
Affbiotech |
1mg |
EUR 195 |
IL-2 Blocking Peptide |
BF0385-BP |
Affbiotech |
1mg |
EUR 195 |
Bcl-2 Blocking Peptide |
BF9103-BP |
Affbiotech |
1mg |
EUR 195 |
MAPKAPK-2 Blocking Peptide |
AF7809-BP |
Affbiotech |
1mg |
EUR 195 |
EFNB1/2 Blocking Peptide |
AF7821-BP |
Affbiotech |
1mg |
EUR 195 |
SHP-2 Blocking Peptide |
AF7853-BP |
Affbiotech |
1mg |
EUR 195 |
HEN1/2 Blocking Peptide |
AF9085-BP |
Affbiotech |
1mg |
EUR 195 |
MKP-2 Blocking Peptide |
AF9113-BP |
Affbiotech |
1mg |
EUR 195 |
PHKA1/2 Blocking Peptide |
AF9155-BP |
Affbiotech |
1mg |
EUR 195 |
Photomedin-2 Blocking Peptide |
AF9157-BP |
Affbiotech |
1mg |
EUR 195 |
Caspase-2 Blocking Peptide |
3027BP-50 |
Biovision |
|
EUR 153 |
Bcl-2 Blocking Peptide |
3033BP-50 |
Biovision |
|
EUR 153 |
MAPKAPK-2 Blocking Peptide |
3100BP-50 |
Biovision |
|
EUR 153 |
Epsin 2 Blocking Peptide |
33R-2101 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EPN2 antibody, catalog no. 70R-2581 |
Synaptogyrin 2 Blocking Peptide |
33R-2727 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SYNGR2 antibody, catalog no. 70R-6322 |
Tetraspanin 2 Blocking Peptide |
33R-2840 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TSPAN2 antibody, catalog no. 70R-6131 |
Nucleobindin 2 Blocking Peptide |
33R-2896 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NUCB2 antibody, catalog no. 70R-1576 |
Hexokinase 2 Blocking Peptide |
33R-3606 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HK2 antibody, catalog no. 70R-5559 |
Pannexin 2 Blocking Peptide |
33R-3625 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PANX2 antibody, catalog no. 70R-1761 |
Plakophilin 2 Blocking Peptide |
33R-3813 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PKP2 antibody, catalog no. 70R-6030 |
Carboxylesterase 2 Blocking Peptide |
33R-3874 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CES2 antibody, catalog no. 70R-3529 |
Cryptochrome 2 Blocking Peptide |
33R-3945 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CRY2 antibody, catalog no. 70R-4034 |
Calbindin 2 Blocking Peptide |
33R-3997 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CALB2 antibody, catalog no. 70R-2905 |
Desmoglein 2 Blocking Peptide |
33R-4430 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DSG2 antibody, catalog no. 70R-6105 |
Prohibitin 2 Blocking Peptide |
33R-4533 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PHB2 antibody, catalog no. 70R-2417 |
Tropomodulin 2 Blocking Peptide |
33R-4840 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TMOD2 antibody, catalog no. 70R-5239 |
Mitofusin 2 Blocking Peptide |
33R-4923 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MFN2 antibody, catalog no. 70R-6461 |
Neurensin 2 Blocking Peptide |
33R-5159 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NRSN2 antibody, catalog no. 70R-6743 |
Protor 2 Blocking Peptide |
33R-5255 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FLJ14213 antibody, catalog no. 70R-3938 |
Septin 2 Blocking Peptide |
33R-5309 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT2 antibody, catalog no. 70R-5633 |
Transportin 2 Blocking Peptide |
33R-5534 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNPO2 antibody, catalog no. 70R-2016 |
Transglutaminase 2 Blocking Peptide |
33R-5634 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TGM2 antibody, catalog no. 70R-6050 |
Secernin 2 Blocking Peptide |
33R-5762 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SCRN2 antibody, catalog no. 70R-4388 |
ILP-2 Blocking Peptide |
3337BP-50 |
Biovision |
|
EUR 153 |
Cox-2 Blocking Peptide |
3362BP-50 |
Biovision |
|
EUR 153 |
Cox-2 Blocking Peptide |
3362RBP-50 |
Biovision |
|
EUR 153 |
Calpain-2 Blocking Peptide |
3372BP-50 |
Biovision |
|
EUR 153 |
Calponin 2 Blocking Peptide |
33R-10105 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CNN2 antibody, catalog no. 70R-2274 |
Metaxin 2 Blocking Peptide |
33R-10130 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MTX2 antibody, catalog no. 70R-2450 |
Caspase 2 Blocking Peptide |
33R-10441 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 2 antibody, catalog no. 20R-1431 |
MAPKAPK 2 Blocking Peptide |
33R-10447 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MAPKAPK 2 antibody, catalog no. 20R-1452 |
Cox 2 Blocking Peptide |
33R-10476 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Cox 2 antibody, catalog no. 20R-1526 |
Wnt 2 Blocking Peptide |
33R-10509 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 2 antibody, catalog no. 20R-1650 |
HDAC 2 Blocking Peptide |
33R-10517 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 2 antibody, catalog no. 20R-1662 |
HAT 2 Blocking Peptide |
33R-10542 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HAT 2 antibody, catalog no. 20R-1707 |
Sox 2 Blocking Peptide |
33R-10563 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Sox 2 antibody, catalog no. 20R-1751 |
ICAM 2 Blocking Peptide |
33R-10568 |
Fitzgerald |
50 ug |
EUR 349 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ICAM 2 antibody, catalog no. 20R-1756 |
Caspase 2 Blocking Peptide |
33R-10597 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 2 antibody, catalog no. 70R-11565 |
Calpain 2 Blocking Peptide |
33R-10734 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Calpain 2 antibody, catalog no. 70R-11784 |
Lipocalin 2 Blocking Peptide |
33R-10933 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Lipocalin 2 antibody, catalog no. 70R-12115 |
Lipin 2 Blocking Peptide |
33R-10945 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Lipin 2 antibody, catalog no. 70R-12128 |
We report that the alteration of mitochondrial perform in key tissues is crucial for establishing and sustaining a professionallongevity cue. We discover that regulators of mitochondrial stress responses are important and particular genetic necessities for the electron transport chain (ETC) longevity pathway. Strikingly, we discover that mitochondrial perturbation in one tissue is perceived and acted upon by the mitochondrial stress response pathway in a distal tissue.