Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Cells from organisms with renewable tissues can completely withdraw from the cell cycle in response to various stress, together with dysfunctional telomeres, DNA harm, sturdy mitogenic alerts, and disrupted chromatin. This response, termed mobile senescence, is managed by the p53 and RB tumor suppressor proteins and constitutes a potent anticancer mechanism.

Nonetheless, senescent cells purchase phenotypic modifications which will contribute to ageing and sure age-related ailments, together with late-life most cancers. Thus, the senescence response could also be antagonistically pleiotropic, selling early-life survival by curbing the event of most cancers however ultimately limiting longevity as dysfunctional senescent cells accumulate.

Numerous research reveal hyperlinks between persistent stress and indices of poor well being, together with danger components for heart problems and poorer immune operate. Nevertheless, the precise mechanisms of how stress will get “underneath the pores and skin” stay elusive. We investigated the speculation that stress impacts well being by modulating the speed of mobile ageing.

Here we offer proof that psychological stress–both perceived stress and chronicity of stress–is considerably related to larger oxidative stress, decrease telomerase exercise, and shorter telomere size, that are recognized determinants of cell senescence and longevity, in peripheral blood mononuclear cells from wholesome premenopausal girls. Women with the very best ranges of perceived stress have telomeres shorter on common by the equal of no less than one decade of further ageing in comparison with low stress girls. These findings have implications for understanding how, on the mobile degree, stress might promote earlier onset of age-related ailments.

The Caenorhabditis elegans transcription issue HSF-1, which regulates the heat-shock response, additionally influences ageing. Reducing hsf-1 exercise accelerates tissue ageing and shortens life-span, and we present that hsf-1 overexpression extends lifespan. We discover that HSF-1, just like the transcription issue DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to increase life-span.

Our findings counsel it is because HSF-1 and DAF-16 collectively activate expression of particular genes, together with genes encoding small heat-shock proteins, which in flip promote longevity. The small heat-shock proteins additionally delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the conventional ageing course of to such a age-related illness.

The SIR2/3/four advanced and SIR2 alone promote longevity in Saccharomyces cerevisiae by two completely different mechanisms.

 

The SIR genes are determinants of life span in yeast mom cells. Here we present that life span regulation by the Sir proteins is unbiased of their position in nonhomologous finish becoming a member of. The quick life span of a sir3 or sir4 mutant is as a result of simultaneous expression of a and alpha mating-type data, which not directly causes a rise in rDNA recombination and possible will increase the manufacturing of extrachromosomal rDNA circles.
The quick life span of a sir2 mutant additionally reveals a direct failure to repress recombination generated by the Fob1p-mediated replication block within the rDNA. Sir2p is a limiting element in selling yeast longevity, and rising the gene dosage extends the life span in wild-type cells. A attainable position of the conserved SIR2 in mammalian ageing is mentioned.
Calorie restriction extends life-span in all kinds of organisms. Although it has been steered that calorie restriction may match by lowering the degrees of reactive oxygen species produced throughout respiration, the mechanism by which this routine slows ageing is unsure. Here, we mimicked calorie restriction in yeast by physiological or genetic means and confirmed a considerable extension in life-span. This extension was not noticed in strains mutant for SIR2 (which encodes the silencing protein Sir2p) or NPT1 (a gene in a pathway within the synthesis of NAD, the oxidized type of nicotinamide adenine dinucleotide). These findings counsel that the elevated longevity induced by calorie restriction requires the activation of Sir2p by NAD.
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that features in an insulin/insulin-like development issue (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates grownup longevity. We discovered that mutation of chico extends fruit fly median life-span by as much as 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a results of impaired oogenesis in chico females, nor was it persistently correlated with elevated stress resistance. The dwarf phenotype of chico homozygotes was additionally pointless for extension of life-span. The position of insulin/IGF signaling in regulating animal ageing is due to this fact evolutionarily conserved.
 Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Autophagy and ageing.

 

To decide the position of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and most life spans had been maximally elevated (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract improvement had been delayed, oxidative harm was diminished, H2O2 manufacturing and H2O2-induced aconitase inactivation had been attenuated, and the event of mitochondrial deletions was diminished. These outcomes help the free radical concept of ageing and reinforce the significance of mitochondria as a supply of those radicals.

Genetic inhibition of autophagy induces degenerative modifications in mammalian tissues that resemble these related to ageing, and regular and pathological ageing are sometimes related to a diminished autophagic potential. Pharmacological or genetic manipulations that improve life span in mannequin organisms typically stimulate autophagy, and its inhibition compromises the longevity-promoting results of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin development issue signaling, or the administration of rapamycin, resveratrol, or spermidine.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

4-SEP312Hu
  • EUR 5240.00
  • EUR 2769.00
  • EUR 693.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-10x96wellstestplate 10x96-wells test plate
EUR 5189.65
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-1x48wellstestplate 1x48-wells test plate
EUR 515.03
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

SEP312Hu-1x96wellstestplate 1x96-wells test plate
EUR 692.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RD-LASS2-Hu-48Tests 48 Tests
EUR 563

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RD-LASS2-Hu-96Tests 96 Tests
EUR 783

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

DLR-LASS2-Hu-48T 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

DLR-LASS2-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

20-abx152171
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit

abx388232-96tests 96 tests
EUR 911

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RDR-LASS2-Hu-48Tests 48 Tests
EUR 589

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit

RDR-LASS2-Hu-96Tests 96 Tests
EUR 820

Human Longevity Assurance Homolog 2 (LASS2) Protein

20-abx654210
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

LAG1 Longevity Assurance Homolog 2 (LASS2) Antibody

abx019124-100ug 100 ug
EUR 342

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit

20-abx496121
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)

ELK7214 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Longevity Assurance Homolog 6 (LASS6) Antibody

abx029719-400ul 400 ul
EUR 523

Longevity Assurance Homolog 6 (LASS6) Antibody

abx029719-80l 80 µl
EUR 286

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-10x96wellstestplate 10x96-wells test plate
EUR 5189.65
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-1x48wellstestplate 1x48-wells test plate
EUR 515.03
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-1x96wellstestplate 1x96-wells test plate
EUR 692.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

SER156Hu-5x96wellstestplate 5x96-wells test plate
EUR 2818.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

4-SER156Hu
  • EUR 5240.00
  • EUR 2769.00
  • EUR 693.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit

20-abx258682
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)

KTE61853-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody

20-abx008040
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody

20-abx013801
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody

abx430427-200ul 200 ul
EUR 384

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit

20-abx496220
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)

ELK7613 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E09A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E08A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E01A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E01A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E03A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E02A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E07A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E06A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E04A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)

KTE61852-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit

E05A0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody

abx432242-200ul 200 ul
EUR 384

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 1
EUR 202

AXYPET STARTER KIT 2 AP-10, AP-100 & AP-1000 WITH ADDITIONAL FREE RACKS OF AXYGEN PIPETTE TIPS

AP-STR-KIT-2 1/pk
EUR 367
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Nori Human TIM-2 ELISA Kit-2 Plates

GR111039-2 2 x 96-well
EUR 832

Nori Equine MMP-2 ELISA Kit-2 Plates

GR106478-2 2 x 96-well
EUR 832

Nori Equine TIM-2 ELISA Kit (2 plates)

GR106516-2 2 x 96-well
EUR 832

Nori Canine TIM-2 ELISA Kit (2 plates)

GR115041-2 2 x 96-well
EUR 832

Nori® Human Angiopoietin-2 (ANG-2) ELISA Kit (2 plates)

GR106245-2 2 x 96-well
EUR 832

Nori Equine MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106502-2 2 x 96-well
EUR 832

Nori® Rabbit IL-2 ELISA Kit- 2 Plates

GR144032-2 2 x 96-well
EUR 832

Nori® Monkey IL-2 ELISA Kit- 2 Plates

GR169004-2 2 x 96-well
EUR 832

Nori® Donkey IL-2 ELISA Kit- 2 Plates

GR170004-2 2 x 96-well
EUR 832

Nori® Porcine MMP-2 ELISA Kit- 2 Plates

GR113006-2 2 x 96-well
EUR 832

Nori® Mouse IL-2 ELISA Kit- 2 Plates

GR117024-2 2 x 96-well
EUR 832

Nori® Mouse IGFBP-2 ELISA Kit- 2 Plates

GR117043-2 2 x 96-well
EUR 832

Nori® Chicken Netrin-2 ELISA Kit (2 plates)

GR106184-2 2 x 96-well
EUR 832

Nori® Human Tie-2 ELISA Kit (2 plates)

GR106458-2 2 x 96-well
EUR 832

Nori® Human TIMP-2 ELISA Kit (2 plates)

GR106460-2 2 x 96-well
EUR 832

Nori® Human Trappin-2 ELISA Kit (2 plates)

GR106467-2 2 x 96-well
EUR 832

Nori® Chicken MMP-2 ELISA Kit- 2 Plates

GR114008-2 2 x 96-well
EUR 832

Nori® Chicken IGFBP-2 ELISA Kit-2 Plates

GR114026-2 2 x 96-well
EUR 832

Nori® Human b-defensin 2 (BD-2) ELISA Kit- 2 Plates

GR111099-2 2 x 96-well
EUR 832

Nori® Human MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106372-2 2 x 96-well
EUR 832

Nori® Guinea Pig IL-2 ELISA Kit- 2 Plates

GR171004-2 2 x 96-well
EUR 832

Nori® Porcine b-defensin 2 ELISA Kit- 2 Plates

GR113081-2 2 x 96-well
EUR 832

Nori® Canine (dog) IL-2 ELISA Kit (2 plates)

GR106163-2 2 x 96-well
EUR 832

Nori® Porcine (pig) IL-2 ELISA Kit (2 plates)

GR106188-2 2 x 96-well
EUR 832

Nori Human A1AT ELISA Kit-2 Plates

GR111022-2 2 x 96-well
EUR 832

Nori Human A1PI ELISA Kit-2 Plates

GR111023-2 2 x 96-well
EUR 832

Nori Human LDHA ELISA Kit-2 Plates

GR111024-2 2 x 96-well
EUR 832

Nori Human CRP ELISA Kit-2 Plates

GR111025-2 2 x 96-well
EUR 832

Nori Human ACE ELISA Kit-2 Plates

GR111026-2 2 x 96-well
EUR 832

Nori Human Uteroglobin ELISA Kit-2 Plates

GR111027-2 2 x 96-well
EUR 832

Nori Human eNOS ELISA Kit-2 Plates

GR111031-2 2 x 96-well
EUR 832

Nori Human PCNA ELISA Kit-2 Plates

GR111032-2 2 x 96-well
EUR 832

Nori Human DR3 ELISA Kit-2 Plates

GR111049-2 2 x 96-well
EUR 832

Nori Human HSP27 ELISA Kit-2 Plates

GR111050-2 2 x 96-well
EUR 832

Nori Human TFF1 ELISA Kit-2 Plates

GR111052-2 2 x 96-well
EUR 832

Nori Human GSAP ELISA Kit-2 Plates

GR111053-2 2 x 96-well
EUR 832

Nori Human HSP60 ELISA Kit-2 Plates

GR111055-2 2 x 96-well
EUR 832

Nori Bovine A1AT ELISA Kit-2 Plates

GR112012-2 2 x 96-well
EUR 832

Nori Bovine A1PI ELISA Kit-2 Plates

GR112013-2 2 x 96-well
EUR 832

Nori Bovine LDHA ELISA Kit-2 Plates

GR112014-2 2 x 96-well
EUR 832

Nori Porcine TFF1 ELISA Kit-2 Plates

GR113012-2 2 x 96-well
EUR 832

Nori Porcine GSAP ELISA Kit-2 Plates

GR113013-2 2 x 96-well
EUR 832

Nori Porcine DR3 ELISA Kit-2 Plates

GR113015-2 2 x 96-well
EUR 832

Nori Porcine HSP27 ELISA Kit-2 Plates

GR113016-2 2 x 96-well
EUR 832

Nori Porcine HSP60 ELISA Kit-2 Plates

GR113017-2 2 x 96-well
EUR 832

Nori Porcine IL1R1 ELISA Kit-2 Plates

GR113024-2 2 x 96-well
EUR 832

Nori Porcine IL1R2 ELISA Kit-2 Plates

GR113025-2 2 x 96-well
EUR 832

Nori Porcine Prolactin ELISA Kit (2 plates)

GR113027-2 2 x 96-well
EUR 832

Nori Porcine BANK1 ELISA Kit (2 plates)

GR113029-2 2 x 96-well
EUR 832

Nori Porcine LRRC32 ELISA Kit (2 plates)

GR113031-2 2 x 96-well
EUR 832

Nori Porcine FRAT2 ELISA Kit (2 plates)

GR113032-2 2 x 96-well
EUR 832

Nori Porcine GULP1 ELISA Kit (2 plates)

GR113035-2 2 x 96-well
EUR 832

Nori Porcine PLA2R ELISA Kit (2 plates)

GR113038-2 2 x 96-well
EUR 832

Nori Equine VEGF ELISA Kit-2 Plates

GR106475-2 2 x 96-well
EUR 832

Nori Equine HGF ELISA Kit-2 Plates

GR106477-2 2 x 96-well
EUR 832

Nori Equine A1AT ELISA Kit-2 Plates

GR106490-2 2 x 96-well
EUR 832

Nori Equine A1PI ELISA Kit-2 Plates

GR106491-2 2 x 96-well
EUR 832

Nori Equine LDHA ELISA Kit-2 Plates

GR106492-2 2 x 96-well
EUR 832

Nori Equine CRP ELISA Kit-2 Plates

GR106493-2 2 x 96-well
EUR 832

Nori Equine Uteroglobin ELISA Kit-2 Plates

GR106495-2 2 x 96-well
EUR 832

Nori Equine eNOS ELISA Kit-2 Plates

GR106499-2 2 x 96-well
EUR 832

Nori Equine PCNA ELISA Kit-2 Plates

GR106500-2 2 x 96-well
EUR 832

Nori Equine HMGB1 ELISA Kit (2 plates)

GR106519-2 2 x 96-well
EUR 832

Nori Equine IgM ELISA Kit (2 plates)

GR106524-2 2 x 96-well
EUR 832

Nori Equine IgE ELISA Kit (2 plates)

GR106525-2 2 x 96-well
EUR 832

Nori Equine IgG1 ELISA Kit (2 plates)

GR106526-2 2 x 96-well
EUR 832

Nori Canine A1PI ELISA Kit-2 Plates

GR115016-2 2 x 96-well
EUR 832

Nori Canine LDHA ELISA Kit-2 Plates

GR115017-2 2 x 96-well
EUR 832

Nori Canine CRP ELISA Kit-2 Plates

GR115018-2 2 x 96-well
EUR 832

Nori Canine HMGB1 ELISA Kit (2 plates)

GR115044-2 2 x 96-well
EUR 832

Here, we talk about the possible trigger and impact relationship between perturbed autophagy and ageing, in addition to attainable molecular mechanisms which will mediate the anti-ageing results of autophagy.