HMI-S201

We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer’s Association diagnostic criteria.

HMI sgRNA CRISPR Lentivector (Human) (Target 1)

K0974302 1.0 ug DNA
EUR 154

HMI sgRNA CRISPR Lentivector (Human) (Target 2)

K0974303 1.0 ug DNA
EUR 154

HMI sgRNA CRISPR Lentivector (Human) (Target 3)

K0974304 1.0 ug DNA
EUR 154

HMI Protein Vector (Human) (pPB-C-His)

PV084025 500 ng Ask for price

HMI Protein Vector (Human) (pPB-N-His)

PV084026 500 ng Ask for price

HMI Protein Vector (Human) (pPM-C-HA)

PV084027 500 ng Ask for price

HMI Protein Vector (Human) (pPM-C-His)

PV084028 500 ng Ask for price

HMI 3'UTR GFP Stable Cell Line

TU060007 1.0 ml
EUR 2333

HMI 3'UTR Luciferase Stable Cell Line

TU010007 1.0 ml
EUR 2333

HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728375 1.0 ug DNA Ask for price

HMI Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV728379 1.0 ug DNA Ask for price

HMI Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728380 1.0 ug DNA Ask for price

HMI sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0974305 3 x 1.0 ug
EUR 376

HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV728376 1.0 ug DNA Ask for price

HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV728377 1.0 ug DNA Ask for price

HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV728378 1.0 ug DNA Ask for price

HMI sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0974306 1.0 ug DNA
EUR 167

HMI sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0974307 1.0 ug DNA
EUR 167

HMI sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0974308 1.0 ug DNA
EUR 167

The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies.

CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.