SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

A progressive lack of neurons with age underlies quite a lot of debilitating neurological issues, together with Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), but few efficient therapies are at present accessible. The SIR2 gene promotes longevity in quite a lot of organisms and might underlie the well being advantages of caloric restriction, a weight-reduction plan that delays ageing and neurodegeneration in mammals. Here, we report {that a} human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in main neurons challenged with neurotoxic insults.

In cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, each promote neuronal survival. In the inducible p25 transgenic mouse, a mannequin of AD and tauopathies, resveratrol lowered neurodegeneration in the hippocampus, prevented studying impairment, and decreased the acetylation of the recognized SIRT1 substrates PGC-1alpha and p53. Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred vital safety against neurodegeneration. Thus, SIRT1 constitutes a singular molecular hyperlink between ageing and human neurodegenerative issues and supplies a promising avenue for therapeutic intervention.

Telomere upkeep is assumed to play a task in signaling mobile senescence; nevertheless, a hyperlink with organismal ageing processes has not been established. The telomerase null mouse supplies a possibility to grasp the consequences related to vital telomere shortening on the organismal degree. We studied quite a lot of physiological processes in an ageing cohort of mTR-/- mice. Loss of telomere perform didn’t elicit a full spectrum of classical pathophysiological signs of ageing.

However, age-dependent telomere shortening and accompanying genetic instability have been related to shortened life span in addition to a lowered capability to reply to stresses comparable to wound therapeutic and hematopoietic ablation. In addition, we discovered an elevated incidence of spontaneous malignancies. These findings show a vital function for telomere size in the general health, reserve, and properly being of the ageing organism.

Direct inhibition of the longevity-promoting issue SKN-1 by insulin-like signaling in C. elegans.

 

Insulin/IGF-1-like signaling (IIS) is central to progress and metabolism and has a conserved function in ageing. In C. elegans, reductions in IIS improve stress resistance and longevity, results that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription issue SKN-1 additionally defends against oxidative stress by mobilizing the conserved part 2 detoxing response. Here we present that IIS not solely opposes DAF-16 but additionally straight inhibits SKN-1 in parallel.

The IIS kinases AKT-1, -2, and SGK-1 phosphorylate SKN-1, and lowered IIS results in constitutive SKN-1 nuclear accumulation in the gut and SKN-1 goal gene activation. SKN-1 contributes to the elevated stress tolerance and longevity ensuing from lowered IIS and delays ageing when expressed transgenically. Furthermore, SKN-1 that’s constitutively lively will increase life span independently of DAF-16. Our findings point out that the transcription community regulated by SKN-1 promotes longevity and is a crucial direct goal of IIS.

Aberrant protein aggregation is a typical characteristic of late-onset neurodegenerative ailments, together with Alzheimer’s disease, which is related to the misassembly of the Abeta(1-42) peptide. Aggregation-mediated Abeta(1-42) toxicity was lowered in Caenorhabditis elegans when ageing was slowed by decreased insulin/insulin progress factor-1-like signaling (IIS).

The downstream transcription elements, warmth shock issue 1, and DAF-16 regulate opposing disaggregation and aggregation actions to advertise mobile survival in response to constitutive poisonous protein aggregation. Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these outcomes counsel a mechanistic hyperlink between the ageing course of and aggregation-mediated proteotoxicity.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

SIRT6 hyperlinks histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Members of the sirtuin (SIRT) household of NAD-dependent deacetylases promote longevity in a number of organisms. Deficiency of mammalian SIRT6 results in shortened life span and an ageing-like phenotype in mice, however the underlying molecular mechanisms are unclear. Here we present that SIRT6 capabilities at chromatin to attenuate NF-kappaB signaling.

SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB goal gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these goal promoters is related to elevated RELA promoter occupancy and enhanced NF-kappaB-dependent modulation of gene expression, apoptosis, and mobile senescence.

Computational genomics analyses revealed elevated exercise of NF-kappaB-driven gene expression packages in a number of Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice. We suggest that SIRT6 attenuates NF-kappaB signaling through H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling might contribute to untimely and regular ageing.

The life span of C. elegans will be elevated through lowered perform of the mitochondria; nevertheless, the extent to which mitochondrial alteration in a single, distinct tissue might affect ageing in the entire organism stays unknown. We addressed this query by asking whether or not manipulations to ETC perform can modulate ageing in a cell-non-autonomous style.

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-400ul 400 ul
EUR 627.6

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-80l 80 µl
EUR 343.2

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit
20-abx496121
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu 96T
EUR 505
Description: tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human LASS2(Longevity Assurance Homolog 2) ELISA Kit
ELK7214-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human LASS2(Longevity Assurance Homolog 2) ELISA Kit
ELK7214-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-48T 48T
EUR 610.82

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-5x96T 5x96T
EUR 4144.85

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-96T 96T
EUR 872.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-48T 48T
EUR 416.29

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-5x96T 5x96T
EUR 2824.83

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-96T 96T
EUR 594.7

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DL-LASS2-Hu 96T
EUR 481
Description: tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EK15188 96Т
EUR 768

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit
abx388232-96tests 96 tests
EUR 1093.2

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
20-abx152171
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48T 48T
EUR 493.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48Tests 48 Tests
EUR 675.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96T 96T
EUR 705
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96Tests 96 Tests
EUR 939.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
4-SEP312Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48T 48T
EUR 518.18
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48Tests 48 Tests
EUR 706.8

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96T 96T
EUR 740.25
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96Tests 96 Tests
EUR 984

LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody
abx430427-200ul 200 ul
EUR 460.8

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx008040
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  • 100 ul
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  • 30 ul

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx013801
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  • 100 ug
  • 10 ug
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  • 300 µg

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
abx013801-100l 100 µl
EUR 43.75

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)
ELK7214 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
EK10151 96Т
EUR 799

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
AE35962HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
AE35962HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A8819 96T
EUR 700
Description: ELISA

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit
20-abx496220
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A43740 96T
EUR 700
Description: ELISA

Human LASS6(Longevity Assurance Homolog 6) ELISA Kit
ELK7613-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human LASS6(Longevity Assurance Homolog 6) ELISA Kit
ELK7613-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-48T 48T
EUR 610.82

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-5x96T 5x96T
EUR 4144.85

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-96T 96T
EUR 872.6

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-48T 48T
EUR 380.31

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-5x96T 5x96T
EUR 2580.68

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-96T 96T
EUR 543.3

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
20-abx258682
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  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
4-SER156Hu
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  • Ask for price
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A0054 96T
EUR 700
Description: ELISA

Sheep LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A96033 96T
EUR 700
Description: ELISA

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A17561 96T
EUR 700
Description: ELISA

Canine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A61175 96T
EUR 700
Description: ELISA

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A26308 96T
EUR 700
Description: ELISA

Bovine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A78604 96T
EUR 700
Description: ELISA

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A69887 96T
EUR 700
Description: ELISA

Porcine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A52457 96T
EUR 700
Description: ELISA

Chicken LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A87330 96T
EUR 700
Description: ELISA

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Longevity Assurance Homolog 2 (LASS2) Magnetic Luminex Assay Kit
LKU602152-96T 96T
EUR 1062.6

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)
ELK7613 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E01A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E01A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit
EK10150 96Т
EUR 799

Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit
AE35956HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit
AE35956HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit
AE35958HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit
AE35958HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
AE35965HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
AE35965HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Mouse LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
RK12828 96T
EUR 280

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA Kit
NSL1442Hu 96 wells
EUR 468

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
RK10479 96T
EUR 280

Guinea Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A35022 96T
EUR 700
Description: ELISA

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit
NSL1118Bo 96 T
EUR 528

Canine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit
NSL1145Ca 1240 wells
EUR 528

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6)
KTE61852-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Longevity Assurance Homolog 6 (LASS6) Magnetic Luminex Assay Kit
LKU602157-96T 96T
EUR 1062.6

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-200ul 200 ul
EUR 460.8

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-100g 100 µg
EUR 387.5

Cers2 (GFP-tagged) - Mouse longevity assurance homolog 2 (S. cerevisiae) (Lass2)
MG205931 10 µg Ask for price

Cers6 (GFP-tagged) - Mouse longevity assurance homolog 6 (S. cerevisiae) (Lass6)
MG205998 10 µg Ask for price

Cers4 (GFP-tagged) - Mouse longevity assurance homolog 4 (S. cerevisiae) (Lass4)
MG206130 10 µg Ask for price

Cers5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (Lass5)
MG206528 10 µg Ask for price

LASS2 (untagged)-Human LAG1 longevity assurance homolog 2 (S. cerevisiae) (LASS2), transcript variant 3
SC110410 10 µg Ask for price

Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MG206047 10 µg Ask for price

Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047 10 µg Ask for price

LASS3 (untagged)-Human LAG1 longevity assurance homolog 3 (S. cerevisiae) (cDNA clone MGC:26920 IMAGE:4837657), complete cds
SC122492 10 µg Ask for price

Lenti ORF clone of Lass5 (mGFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047L4 10 µg Ask for price

Lenti ORF clone of Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047L3 10 µg Ask for price

Lenti ORF particles, Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >10^7
MR206047L4V 200 µl Ask for price

Lenti ORF particles, Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >1
MR206047L3V 200 µl Ask for price

Growth Blocking Peptide
046-92 100 μg
EUR 255.96

Human MutY homolog Control/blocking peptide #2
MUTY12-P 100 ug
EUR 196.8

Mouse Tubby/TUB homolog Control/blocking peptide # 2
TUBBY12-P 100 ug
EUR 196.8

Growth Blocking Peptide - FAM Labeled
FG-046-92A 1 nmol
EUR 336.96

Growth Blocking Peptide - Biotin Labeled
B-046-92 20 μg
EUR 336.96

Human Tub Homolog Control/blocking peptide # 3
TUBH31-P 100 ug
EUR 196.8

Growth Blocking Peptide - Rhodamine Labeled
FR-046-92 1 nmol
EUR 336.96

Growth Blocking Peptide - I-125 Labeled
T-046-92 10 μCi
EUR 1145.88

Ras Homolog Family Member G (RHOG) Blocking Peptide
20-abx061112
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Human dapper homolog 1 (DACT1) Control/blocking peptide
AB-23080-P 100 ug
EUR 196.8

Mouse Mitochondrial carrier homolog 2 (Mtch2) Control/blocking peptide
AB-23027-P 100ug
EUR 196.8

Ribosome Biogenesis Regulator Homolog (RRS1) Blocking Peptide
20-abx061186
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Mouse Organic Cation Transporter homolog (OCTN1) Control/blocking peptide #1
OCTN11-P 100 ug
EUR 196.8

Mouse Organic Cation Transporter homolog (OCTN2) Control/blocking peptide #1
OCTN21-P 100 ug
EUR 196.8

Mouse Organic Cation Transporter homolog (OCTN3) Control/blocking peptide #1
OCTN31-P 100 ug
EUR 196.8

MAF1 Homolog, Negative Regulator of RNA Polymerase III (MAF1) Blocking Peptide
20-abx162560
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

We report that the alteration of mitochondrial perform in key tissues is crucial for establishing and sustaining a professionallongevity cue. We discover that regulators of mitochondrial stress responses are important and particular genetic necessities for the electron transport chain (ETC) longevity pathway. Strikingly, we discover that mitochondrial perturbation in one tissue is perceived and acted upon by the mitochondrial stress response pathway in a distal tissue.

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