Human longevity is a fancy phenotype with a major familial part, but little is recognized about its genetic antecedents. Increasing proof from animal fashions means that the insulin/IGF-1 signaling (IIS) pathway is an necessary, evolutionarily conserved organic pathway that influences growing old and longevity. However, so far human knowledge have been scarce. Studies have been hampered by small pattern sizes, lack of exact phenotyping, and inhabitants stratification, amongst different challenges.
Therefore, to extra exactly assess potential genetic contributions to human longevity from genes linked to IIS signaling, we selected a big, homogeneous, long-lived inhabitants of males well-characterized for growing old phenotypes, and we carried out a nested-case management research of 5 candidate longevity genes. Genetic variation inside the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous main alleles between the instances and controls was 2.75 (P = 0.00009; adjusted P = 0.00135).
Long-lived males additionally introduced a number of extra phenotypes linked to wholesome growing old, together with decrease prevalence of most cancers and heart problems, higher self-reported well being, and excessive bodily and cognitive perform, regardless of considerably older ages than controls. Several of those growing old phenotypes had been associated with FOXO3A genotype. Long-lived males additionally exhibited a number of organic markers indicative of larger insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and different growing old phenotypes is warranted in different populations.
Oxidative stress influences cell survival and homeostasis, however the mechanisms underlying the organic results of oxidative stress stay to be elucidated. Here, we reveal that the protein kinase MST1 mediates oxidative-stress-induced cell dying in main mammalian neurons by straight activating the FOXO transcription elements. MST1 phosphorylates FOXO proteins at a conserved website inside the forkhead area that disrupts their interplay with 14-3-Three proteins, promotes FOXO nuclear translocation, and thereby induces cell dying in neurons.
We additionally prolong the MST-FOXO signaling hyperlink to nematodes. Knockdown of the C. elegans MST1 ortholog CST-1 shortens life span and accelerates tissue growing old, whereas overexpression of cst-1 promotes life span and delays growing old. The cst-1-induced life-span extension happens in a daf-16-dependent method. The identification of the FOXO transcription elements as main and evolutionarily conserved targets of MST1 means that MST kinases play necessary roles in various organic processes together with mobile responses to oxidative stress and longevity.
Astrocytes as Perspective Targets of Exercise- and Caloric Restriction-Mimetics
Enhanced psychological and bodily exercise can have constructive results on the perform of growing old mind, each within the experimental animals and human sufferers, though mobile mechanisms underlying these results are presently unclear. There is a rising proof that pre-clinical stage of many neurodegenerative illnesses includes modifications in interactions between astrocytes and neurons. Conversely, astrocytes are strategically positioned to mediate the constructive affect of bodily exercise and food regimen on neuronal perform.
Thus, improvement of therapeutic brokers which might enhance the astroglia-neuron communications in ageing mind is of essential significance. Recent advances in research of mobile mechanisms of mind longevity counsel that astrocyte-neuron communications have a significant function within the useful results of caloric restriction, bodily train and their pharmacological mimetics on synaptic homeostasis and cognitive perform.
In explicit, our current knowledge point out that noradrenaline uptake inhibitor atomoxetine can improve astrocytic Ca2+-signaling and astroglia-driven modulation of synaptic plasticity. Similar results had been exhibited by caloric restriction-mimetics metformin and resveratrol. The emerged knowledge additionally counsel that astrocytes may very well be concerned within the modulatory motion of caloric restriction and its mimetics on neuronal autophagy. Still, the effectivity of astrocyte-targeting compounds in stopping age-related cognitive decline is but to be absolutely explored, specifically within the animal fashions of neurodegenerative illnesses and autophagy impairment.
![FOXO3A genotype is strongly associated with human longevity.](https://attitudefactor.com/wp-content/uploads/2021/03/photo_2020-12-09_23-38-58-300x146.jpg)
Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure
The World Health Organization estimates that solely roughly 25% of range in longevity is defined by genetic elements, whereas the opposite 75% is largely decided by interactions with the bodily and social environments. Indeed, growing old is a multifactorial course of that is influenced by a spread of environmental, sociodemographic, and biopsychosocial elements, all of which could act in live performance to find out the method of growing old.
The international common life expectancy elevated basically over the previous century, towards an growing old inhabitants, correlating with the event and onset of age-related illnesses, primarily from cardiovascular and neurological nature. Therefore, the identification of determinants of wholesome and unhealthy growing old is a significant aim to decrease the burden and socioeconomic prices of age-related illnesses.
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E07A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E08A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E06A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A8819 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E01A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E01A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Human LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E03A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA Kit |
NSL1442Hu |
Sunlong |
96 wells |
EUR 468 |
|
Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A43740 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E04A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E09A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Bovine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit |
NSL1118Bo |
Sunlong |
96 T |
EUR 528 |
|
Canine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit |
NSL1145Ca |
Sunlong |
1240 wells |
EUR 528 |
|
Human LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A0054 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Sheep LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A96033 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A17561 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Canine LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A61175 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A26308 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Bovine LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A78604 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A69887 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Chicken LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A87330 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit |
EK10150 |
SAB |
96Т |
EUR 799 |
|
Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit |
EK10151 |
SAB |
96Т |
EUR 799 |
|
Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit |
AE35956HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 6 (LASS6) ELISA Kit |
AE35956HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit |
AE35958HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit |
AE35958HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit |
AE35962HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit |
AE35962HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit |
AE35965HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
Description: Human (Homo sapiens) |
Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit |
AE35965HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
Description: Human (Homo sapiens) |
Mouse LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit |
RK12828 |
Abclonal |
96T |
EUR 280 |
Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit |
RK10479 |
Abclonal |
96T |
EUR 280 |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit |
E05A0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody |
abx430427-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Guinea Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA |
E01A35022 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-48T |
Abbkine |
48T |
EUR 398.4 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 6 (LASS6) |
KTE61852-96T |
Abbkine |
96T |
EUR 646.8 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 6 (LASS6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-48T |
Abbkine |
48T |
EUR 398.4 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2) |
KTE61853-96T |
Abbkine |
96T |
EUR 646.8 |
|
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
20-abx008040 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
20-abx013801 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
LAG1 Longevity Assurance Homolog 2 (LASS2) Antibody |
abx019124-100ug |
Abbexa |
100 ug |
EUR 410.4 |
|
LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody |
abx013801-100l |
Abbexa |
100 µl |
EUR 43.75 |
Human Longevity Assurance Homolog 2 ELISA Kit |
IHULASS2KT |
Innovative research |
each |
EUR 799 |
|
Description: Human Longevity Assurance Homolog 2 ELISA Kit |
Human LASS2(Longevity Assurance Homolog 2) ELISA Kit |
ELK7214-48T |
ELK Biotech |
48T |
Ask for price |
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Human LASS2(Longevity Assurance Homolog 2) ELISA Kit |
ELK7214-96T |
ELK Biotech |
96T |
Ask for price |
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Human LASS6(Longevity Assurance Homolog 6) ELISA Kit |
ELK7613-48T |
ELK Biotech |
48T |
Ask for price |
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Human LASS6(Longevity Assurance Homolog 6) ELISA Kit |
ELK7613-96T |
ELK Biotech |
96T |
Ask for price |
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DLR-LASS2-Hu |
DL Develop |
96T |
EUR 505 |
|
Description: tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DLR-LASS2-Hu-48T |
DL Develop |
48T |
EUR 664.8 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DLR-LASS2-Hu-96T |
DL Develop |
96T |
EUR 870 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKU09363-48T |
Biomatik Corporation |
48T |
EUR 610.82 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKU09363-5x96T |
Biomatik Corporation |
5x96T |
EUR 4144.85 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKU09363-96T |
Biomatik Corporation |
96T |
EUR 872.6 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKN50474-48T |
Biomatik Corporation |
48T |
EUR 380.31 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKN50474-5x96T |
Biomatik Corporation |
5x96T |
EUR 2580.68 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
EKN50474-96T |
Biomatik Corporation |
96T |
EUR 543.3 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKU05672-48T |
Biomatik Corporation |
48T |
EUR 610.82 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKU05672-5x96T |
Biomatik Corporation |
5x96T |
EUR 4144.85 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKU05672-96T |
Biomatik Corporation |
96T |
EUR 872.6 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKN46783-48T |
Biomatik Corporation |
48T |
EUR 416.29 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKN46783-5x96T |
Biomatik Corporation |
5x96T |
EUR 2824.83 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EKN46783-96T |
Biomatik Corporation |
96T |
EUR 594.7 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
DL-LASS2-Hu |
DL Develop |
96T |
EUR 481 |
|
Description: tissue homogenates, cell lysates or other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
EK15188 |
SAB |
96Т |
EUR 768 |
|
Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit |
abx388232-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
|
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
20-abx258682 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
20-abx152171 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
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Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-48T |
Reddot Biotech |
48T |
EUR 493.5 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 675.6 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-96T |
Reddot Biotech |
96T |
EUR 705 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RD-LASS2-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 939.6 |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6227.58 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 618.04 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 831.48 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
SER156Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3381.66 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit |
4-SER156Hu |
Cloud-Clone |
-
Ask for price
-
Ask for price
-
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|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6227.58 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 618.04 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 831.48 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
SEP312Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3381.66 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
4-SEP312Hu |
Cloud-Clone |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-48T |
Reddot Biotech |
48T |
EUR 518.18 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 706.8 |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-96T |
Reddot Biotech |
96T |
EUR 740.25 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit |
RDR-LASS2-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 984 |
ELISA kit for Human LASS2 (Longevity Assurance Homolog 2) |
ELK7214 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
ELISA kit for Human LASS6 (Longevity Assurance Homolog 6) |
ELK7613 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
LASS2 (untagged)-Human LAG1 longevity assurance homolog 2 (S. cerevisiae) (LASS2), transcript variant 3 |
SC110410 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Longevity Assurance Homolog 2 (LASS2) Antibody |
20-abx173382 |
Abbexa |
-
Ask for price
-
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|
|
|
Longevity Assurance Homolog 2 (LASS2) Antibody |
20-abx177383 |
Abbexa |
-
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-
Ask for price
|
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Longevity Assurance Homolog 2 (LASS2) Antibody |
abx234705-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
Longevity Assurance Homolog 6 (LASS6) Antibody |
abx029719-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Longevity Assurance Homolog 6 (LASS6) Antibody |
abx029719-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit |
20-abx496121 |
Abbexa |
-
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-
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-
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|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit |
20-abx496220 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
LASS3 (untagged)-Human LAG1 longevity assurance homolog 3 (S. cerevisiae) (cDNA clone MGC:26920 IMAGE:4837657), complete cds |
SC122492 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Human Longevity Assurance Homolog 2 (LASS2) Protein |
20-abx654210 |
Abbexa |
-
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-
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-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
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Longevity Assurance Homolog 2 (LASS2) Magnetic Luminex Assay Kit |
LKU602152-96T |
Biomatik Corporation |
96T |
EUR 1062.6 |
Longevity Assurance Homolog 6 (LASS6) Magnetic Luminex Assay Kit |
LKU602157-96T |
Biomatik Corporation |
96T |
EUR 1062.6 |
Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody |
abx432242-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody |
abx432242-100g |
Abbexa |
100 µg |
EUR 387.5 |
Cers2 (GFP-tagged) - Mouse longevity assurance homolog 2 (S. cerevisiae) (Lass2) |
MG205931 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Cers6 (GFP-tagged) - Mouse longevity assurance homolog 6 (S. cerevisiae) (Lass6) |
MG205998 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Cers4 (GFP-tagged) - Mouse longevity assurance homolog 4 (S. cerevisiae) (Lass4) |
MG206130 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Cers5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (Lass5) |
MG206528 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704) |
MG206047 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704) |
MR206047 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lass5 (mGFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704) |
MR206047L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704) |
MR206047L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF particles, Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >10^7 |
MR206047L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >1 |
MR206047L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Porcine B7 Homolog 3 ELISA kit |
E01A54073 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Slit Homolog 3 ELISA kit |
E01A60407 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Chromobox Homolog 3 ELISA kit |
E01A54681 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Snail Homolog ELISA kit |
E01A60353 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Slit Homolog 2 ELISA kit |
E01A60109 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Frizzied homolog 8 ELISA kit |
E01A56882 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine BET1 homolog(BET1) ELISA kit |
E01A54236 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein δ Homolog 1 ELISA kit |
E01A56578 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Slit2(Slit Homolog 2) ELISA Kit |
EP0151 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 0.188 ng/ml |
Slit2 ELISA Kit| Porcine Slit Homolog 2 ELISA Kit |
EF016691 |
Lifescience Market |
96 Tests |
EUR 826.8 |
Porcine Achaete scute homolog 3(ASCL3) ELISA kit |
E01A52821 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Crumbs protein homolog 3(CRB3) ELISA kit |
E01A55903 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine BUD13 homolog(BUD13) ELISA kit |
E01A54306 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Yorkie homolog(YAP1) ELISA kit |
E01A61068 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein canopy homolog 3(CNPY3) ELISA kit |
E01A59549 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein canopy homolog 3, CNPY3 ELISA KIT |
ELI-10589p |
Lifescience Market |
96 Tests |
EUR 1113.6 |
Porcine Achaete scute homolog 1 ELISA kit |
E01A52463 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Hedgehog Homolog, Sonic ELISA kit |
E01A60103 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Smoothened homolog(SMO) ELISA kit |
E01A60297 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein pellino homolog 1 ELISA kit |
E01A59344 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Mothers against decapentaplegic homolog 3 ELISA kit |
E01A60111 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Hedgehog Homolog, Indian ELISA kit |
E01A57627 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein dachsous homolog 2 ELISA kit |
E01A56597 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Slit Homolog 2(Slit2) ELISA Kit |
NSL0150Po |
Sunlong |
96T |
EUR 528 |
|
Porcine Anterior Gradient Homolog 2 ELISA kit |
E01A52571 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Adrenocortical Dysplasia Homolog ELISA kit |
E01A52654 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Crumbs homolog 1(CRB1) ELISA kit |
E01A55901 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Crumbs homolog 2(CRB2) ELISA kit |
E01A55902 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein unc-13 homolog D ELISA kit |
E01A58482 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Enhancer of zeste homolog 2 ELISA kit |
E01A56642 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Teashirt homolog 2, TSHZ2 ELISA KIT |
ELI-40365p |
Lifescience Market |
96 Tests |
EUR 1113.6 |
Porcine Protein Muted homolog(MUTED) ELISA kit |
E01A59564 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Protein Muted homolog, MUTED ELISA KIT |
ELI-36857p |
Lifescience Market |
96 Tests |
EUR 1113.6 |
Porcine seminal plasma protein homolog 1 ELISA kit |
E01A54290 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
The function of environmental elements (comparable to air air pollution and noise publicity) as essential determinants of the growing old course of are being more and more acknowledged. Here, we critically assessment current findings in regards to the pathomechanisms underlying the growing old course of and their correlates in cardiovascular and neurological illness, centered on oxidative stress and irritation, in addition to the affect of outstanding environmental pollution, particularly air air pollution and visitors noise publicity.