Sirtuins in mammals: insights into their bioalogical function.

Sirtuins in mammals: insights into their bioalogical function.

Sirtuins are a conserved household of proteins discovered in all domains of life. The first identified sirtuin, Sir2 (silent data regulator 2) of Saccharomyces cerevisiae, from which the household derives its title, regulates ribosomal DNA recombination, gene silencing, DNA restore, chromosomal stability and longevity. Sir2 homologues additionally modulate lifespan in worms and flies, and should underlie the useful results of caloric restriction, the one routine that slows growing older and extends lifespan of most lessons of organism, together with mammals.

Sirtuins have gained appreciable consideration for their influence on mammalian physiology, since they could present novel targets for treating illnesses related to growing older and maybe lengthen human lifespan. In this assessment we describe our present understanding of the biological operate of the seven mammalian sirtuins, SIRT1-7, and we will even focus on their potential as mediators of caloric restriction and as pharmacological targets to delay and deal with human age-related illnesses.

The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors in addition to to Caenorhabditis elegans daf-2, a sign transducer regulating worm dauer formation and grownup longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with as much as an 85% extension of grownup longevity and dwarf males with decreased late age-specific mortality.

Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy towards that of wild-type controls. We conclude that juvenile hormone deficiency, which ends up from InR sign pathway mutation, is ample to increase life-span, and that in flies, insulin-like ligands nonautonomously mediate growing older by retardation of progress or activation of particular endocrine tissue.

FOXO transcription components on the interface between longevity and tumor suppression.

 

A variety of human illnesses, together with most cancers, has a hanging age-dependent onset. However, the molecular mechanisms that join growing older and most cancers are simply starting to be unraveled. FOXO transcription components are promising candidates to function molecular hyperlinks between longevity and tumor suppression. These components are main substrates of the protein kinase Akt.

In the presence of insulin and progress components, FOXO proteins are relocalized from the nucleus to the cytoplasm and degraded through the ubiquitin-proteasome pathway. In the absence of progress components, FOXO proteins translocate to the nucleus and upregulate a sequence of goal genes, thereby selling cell cycle arrest, stress resistance, or apoptosis.

Stress stimuli additionally set off the relocalization of FOXO components into the nucleus, thus permitting an adaptive response to emphasize stimuli. Consistent with the notion that stress resistance is very coupled with lifespan extension, activation of FOXO transcription components in worms and flies will increase longevity. Emerging proof additionally means that FOXO components play a tumor suppressor position in a wide range of cancers. Thus, FOXO proteins translate environmental stimuli into modifications in gene expression applications which will coordinate organismal longevity and tumor suppression.

Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all enhance the life spans of mannequin organisms. These mutations have revealed evolutionarily conserved pathways for growing older, a few of which seem to increase life span in response to sensory cues, caloric restriction, or stress. Many mutations affecting longevity pathways delay age-related illness, and the molecular evaluation of those pathways is resulting in a mechanistic understanding of how these two processes–growing older and illness susceptibility–are linked.

Sirtuins in mammals: insights into their bioalogical function.

Inflammgrowing older and anti-inflammgrowing older: a systemic perspective on growing older and longevity emerged from research in people.

 

A big a part of the growing older phenotype, together with immunosenescence, is defined by an imbalance between inflammatory and anti-inflammatory networks, which ends up in the low grade persistent pro-inflammatory standing we proposed to name inflammgrowing older. Within this angle, wholesome growing older and longevity are possible the outcome not solely of a decrease propensity to mount inflammatory responses but additionally of environment friendly anti-inflammatory networks, which in regular growing older fail to completely neutralize the inflammatory processes consequent to the lifelong antigenic burden and publicity to damgrowing older brokers.

Such a world imbalance could be a main driving pressure for frailty and widespread age-related pathologies, and needs to be addressed and studied inside an evolutionary-based programs biology perspective. Evidence in favor of this conceptualization largely derives from research in people. We thus suggest that inflammgrowing older could be flanked by anti-inflammgrowing older as main determinants not solely of immunosenescence however ultimately of world growing older and longevity.

The FoxO household of Forkhead transcription components performs an vital position in longevity and tumor suppression by upregulating goal genes concerned in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription components translate a wide range of environmental stimuli, together with insulin, progress components, vitamins and oxidative stress, into particular gene-expression applications.

These environmental stimuli management FoxO exercise primarily by regulating their subcellular localization, but additionally by affecting their protein ranges, DNA-binding properties and transcriptional exercise. The exact regulation of FoxO transcription components is enacted by an intricate mixture of post-translational modifications (PTMs), together with phosphorylation, acetylation and ubiquitination, and binding protein companions.

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
EK10151 96Т
EUR 799

Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit
AE35958HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 4 (LASS4) ELISA Kit
AE35958HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
AE35962HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 2 (LASS2) ELISA Kit
AE35962HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
AE35965HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
AE35965HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA Kit
NSL1442Hu 96 wells
EUR 468

Human LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
RK10479 96T
EUR 280

Human LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A0054 96T
EUR 700
Description: ELISA

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human LAG1 longevity assurance homolog 2 (LASS2)
KTE61853-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human LAG1 longevity assurance homolog 2 (LASS2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E02A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E07A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E08A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E06A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A8819 96T
EUR 700
Description: ELISA

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E03A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse LAG1 longevity assurance homolog 1 (LASS1) ELISA Kit
RK12828 96T
EUR 280

Goat LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A43740 96T
EUR 700
Description: ELISA

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E04A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E09A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit
NSL1118Bo 96 T
EUR 528

Canine LAG1 longevity assurance homolog 3(LASS3) ELISA Kit
NSL1145Ca 1240 wells
EUR 528

Sheep LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A96033 96T
EUR 700
Description: ELISA

Mouse LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A17561 96T
EUR 700
Description: ELISA

Canine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A61175 96T
EUR 700
Description: ELISA

Rabbit LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A26308 96T
EUR 700
Description: ELISA

Bovine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A78604 96T
EUR 700
Description: ELISA

Monkey LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A69887 96T
EUR 700
Description: ELISA

Porcine LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A52457 96T
EUR 700
Description: ELISA

Chicken LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A87330 96T
EUR 700
Description: ELISA

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig LAG1 longevity assurance homolog 3 (LASS3) ELISA kit
E05A0057-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig LAG1 longevity assurance homolog 3 (LASS3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea Pig LAG1 longevity assurance homolog 3 (LASS3) ELISA
E01A35022 96T
EUR 700
Description: ELISA

LAG1 Longevity Assurance Homolog 3 (LASS3) Antibody
abx430427-200ul 200 ul
EUR 460.8

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx008040
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  • 100 ul
  • 200 ul
  • 30 ul

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
20-abx013801
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  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

LAG1 Longevity Assurance Homolog 2 (LASS2) Antibody
abx019124-100ug 100 ug
EUR 410.4

LAG1 Longevity Assurance Homolog 4 (LASS4) Antibody
abx013801-100l 100 µl
EUR 43.75

Human LASS6(Longevity Assurance Homolog 6) ELISA Kit
ELK7613-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human LASS6(Longevity Assurance Homolog 6) ELISA Kit
ELK7613-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS6. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS6, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS6 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-48T 48T
EUR 610.82

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-5x96T 5x96T
EUR 4144.85

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKU09363-96T 96T
EUR 872.6

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-48T 48T
EUR 380.31

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-5x96T 5x96T
EUR 2580.68

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
EKN50474-96T 96T
EUR 543.3

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
20-abx258682
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
SER156Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 6 (LASS6) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 6 (LASS6) ELISA Kit
4-SER156Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 6 (LASS6) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 ELISA Kit
IHULASS2KT each
EUR 799
Description: Human Longevity Assurance Homolog 2 ELISA Kit

ELISA kit for Human LASS6 (Longevity Assurance Homolog 6)
ELK7613 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human LASS2(Longevity Assurance Homolog 2) ELISA Kit
ELK7214-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human LASS2(Longevity Assurance Homolog 2) ELISA Kit
ELK7214-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LASS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LASS2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human LASS2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LASS2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu 96T
EUR 505
Description: tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DLR-LASS2-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-48T 48T
EUR 610.82

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-5x96T 5x96T
EUR 4144.85

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKU05672-96T 96T
EUR 872.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-48T 48T
EUR 416.29

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-5x96T 5x96T
EUR 2824.83

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EKN46783-96T 96T
EUR 594.7

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
DL-LASS2-Hu 96T
EUR 481
Description: tissue homogenates, cell lysates or other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
EK15188 96Т
EUR 768

Human Longevity Assurance Homolog 2 (CERS2) ELISA Kit
abx388232-96tests 96 tests
EUR 1093.2

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
20-abx152171
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48T 48T
EUR 493.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-48Tests 48 Tests
EUR 675.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96T 96T
EUR 705
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RD-LASS2-Hu-96Tests 96 Tests
EUR 939.6

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
SEP312Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Longevity Assurance Homolog 2 (LASS2) in Tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
4-SEP312Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Longevity Assurance Homolog 2 (LASS2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48T 48T
EUR 518.18
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-48Tests 48 Tests
EUR 706.8

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96T 96T
EUR 740.25
Description: tissue homogenates, cell lysates and other biological fluids.

Human Longevity Assurance Homolog 2 (LASS2) ELISA Kit
RDR-LASS2-Hu-96Tests 96 Tests
EUR 984

Human Longevity Assurance Homolog 6 (LASS6) CLIA Kit
20-abx496220
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Human LASS2 (Longevity Assurance Homolog 2)
ELK7214 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Longevity Assurance Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-400ul 400 ul
EUR 627.6

Longevity Assurance Homolog 6 (LASS6) Antibody
abx029719-80l 80 µl
EUR 343.2

LASS2 (untagged)-Human LAG1 longevity assurance homolog 2 (S. cerevisiae) (LASS2), transcript variant 3
SC110410 10 µg Ask for price

Human Longevity Assurance Homolog 2 (LASS2) CLIA Kit
20-abx496121
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Longevity Assurance Homolog 2 (LASS2) Protein
20-abx654210
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

LASS3 (untagged)-Human LAG1 longevity assurance homolog 3 (S. cerevisiae) (cDNA clone MGC:26920 IMAGE:4837657), complete cds
SC122492 10 µg Ask for price

Longevity Assurance Homolog 2 (LASS2) Antibody
20-abx173382
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  • 1 mg
  • 200 ug

Longevity Assurance Homolog 2 (LASS2) Antibody
20-abx177383
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  • Ask for price
  • 1 mg
  • 200 ug

Longevity Assurance Homolog 2 (LASS2) Antibody
abx234705-100ug 100 ug
EUR 661.2

Longevity Assurance Homolog 6 (LASS6) Magnetic Luminex Assay Kit
LKU602157-96T 96T
EUR 1062.6

Longevity Assurance Homolog 2 (LASS2) Magnetic Luminex Assay Kit
LKU602152-96T 96T
EUR 1062.6

Cers6 (GFP-tagged) - Mouse longevity assurance homolog 6 (S. cerevisiae) (Lass6)
MG205998 10 µg Ask for price

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-200ul 200 ul
EUR 460.8

Longevity Assurance Gene 1 Protein Homolog 1 (LASS1) Antibody
abx432242-100g 100 µg
EUR 387.5

Cers2 (GFP-tagged) - Mouse longevity assurance homolog 2 (S. cerevisiae) (Lass2)
MG205931 10 µg Ask for price

Cers4 (GFP-tagged) - Mouse longevity assurance homolog 4 (S. cerevisiae) (Lass4)
MG206130 10 µg Ask for price

Cers5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (Lass5)
MG206528 10 µg Ask for price

Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MG206047 10 µg Ask for price

Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047 10 µg Ask for price

Lenti ORF clone of Lass5 (mGFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047L4 10 µg Ask for price

Lenti ORF clone of Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704)
MR206047L3 10 µg Ask for price

Lenti ORF particles, Lass5 (GFP-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >10^7
MR206047L4V 200 µl Ask for price

Lenti ORF particles, Lass5 (Myc-DDK-tagged) - Mouse longevity assurance homolog 5 (S. cerevisiae) (cDNA clone MGC:57962 IMAGE:6419704), 200ul, >1
MR206047L3V 200 µl Ask for price

Assurance Grade Chromium +6 for ICP 1000 ug/mL (1000 PPM) 125mL in H2O - 125ML
SPEC-CR6 125ML
EUR 83.7

Assurance Grade Chromium +6 for ICP 1000 ug/mL (1000 PPM) 30mL in H2O - 30ML
SPEC-CR6M 30ML
EUR 43.2

Assurance Grade Selenium +6 for ICP 1000 ug/mL (1000 PPM) 125mL in H2O - 125ML
SPEC-SE6 125ML
EUR 87.75

Assurance Grade Selenium +6 for ICP 1000 ug/mL (1000 PPM)30mL in H2O - 30ML
SPEC-SE6M 30ML
EUR 39.15

Assurance Grade Chromium +6 for AA and ICP 1000 ug/mL (1000 PPM) 500mL in H2O - 500ML
PLCR9-2X 500ML
EUR 170.1

Assurance Grade Chromium +6 for AA and ICP 10000 ug/mL (10000 PPM) 500mL in H2O - 500ML
PLCR9-3X 500ML
EUR 287.55

Assurance Grade Water Blank for ICP 500mL
PLBLK-HCL 500ML
EUR 58.29

Assurance Grade Water Blank for ICP 1 L - 1L
PLBLK-H2O-1L 1L
EUR 117.45

Assurance Grade Water Blank for ICP 2 L - 2L
PLBLK-H2O-2L 2L
EUR 147.15

Assurance Grade Water Blank for ICP 4 L - 4L
PLBLK-H2O-4L 4L
EUR 170.1

Assurance Grade Water Blank for ICP 500mL - 500ML
PLBLK-H2O 500ML
EUR 98.55

Assurance Grade Arsenic +5 for ICP 1000 ug/mL (1000 PPM) 125mL in H2O - 125ML
SPEC-AS5 125ML
EUR 83.7

Assurance Grade Boron for AA and ICP 1000 ug/mL (1000 PPM) 30mL in H2O - 30ML
PLB9-2M 30ML
EUR 39.15

Assurance Grade Boron for AA and ICP 1000 ug/mL (1000 PPM) 250mL in H2O - 250ML
PLB9-2T 250ML
EUR 125.55

Assurance Grade Boron for AA and ICP 1000 ug/mL (1000 PPM) 500mL in H2O - 500ML
PLB9-2Y011 500ML
EUR 162

Assurance Grade Boron for AA and ICP 10000 ug/mL (10000 PPM) 500mL in H2O - 500ML
PLB9-3X 500ML
EUR 287.55

Assurance Grade Boron for AA and ICP 10000 ug/mL (10000 PPM) 125mL in H2O - 125ML
PLB9-3Y 125ML
EUR 121.5

Assurance Grade Boron for AA and ICP 1000 ug/mL (1000 PPM) 125mL in H2O - 125ML
PLB92Y 125ML
EUR 72.9

Assurance Grade Aresenic +5 for ICP 1000 ug/mL (1000 PPM) 30mL in H2O - 30ML
SPEC-AS5M 30ML
EUR 39.15

Assurance Grade Nitric Acid Blank for ICP 500mL - 500ML
PLBLK-HNO3 500ML
EUR 98.55

An intriguing chance is that FoxO PTMs could act as a ‘molecular FoxO code’ learn by selective protein companions to quickly regulate gene-expression applications. The efficient management of FoxO exercise in response to environmental stimuli is prone to be important to stop growing older and age-dependent illnesses, together with most cancers, neurodegenerative illnesses and diabetes.

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